Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear
Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear
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褪黑激素及其受体（褪黑激素 1a 和 1b 受体）在小鼠内耳中的定位
DOI：
10.1080/00016489.2019.1655587
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Anniko M
中科院分区：
文献类型：
--
作者：
Takumida M;Anniko M
背景：在内耳中，已经收集的证据表明褪黑激素在内耳生理学和病理生理学中起重要作用。然而，以前没有尝试调查褪黑素及其受体在整个innerear.Aims/objectives的定位或表达：分析褪黑素及其受体在正常小鼠内耳的存在。结果：耳蜗、前庭终器、前庭神经节、前庭感觉细胞、前庭暗细胞、前庭移行细胞、内淋巴囊上皮细胞对MT 1a和MT 1b呈免疫荧光反应。结论：MT 1a和MT 1b在耳蜗、前庭终器、前庭神经节和内淋巴囊中的分布与MT 1a和MT 1b的表达密切相关。目前的研究结果表明，褪黑激素及其受体，（MT 1a和MT 1b）存在于内耳中，从而支持褪黑激素在内耳中起生理作用的假设。
Background:In the inner ear, evidence has been gathered indicating that melatonin plays important roles in inner ear physiology and pathophysiology. However, no attempt has been made previously to investigate the localization or expression of melatonin and its receptors in the whole inner ear.Aims/objectives:To analyze the presence of melatonin and its receptors in the normal mouse inner ear.Material and methods:C57BL6/J mice were used in this study. The localizations of melatonin, MT1a and MT1b in the inner ear, i.e. cochlea, vestibular end organs, vestibular ganglion and endolymphatic sac (ES), were studied by immunohistochemistry.Results:The organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory cells, vestibular dark and transitional cells, and ES epithelial cells showed an immunofluorescence reaction to melatonin, MT1a and MT1b.Conclusion and significance:The present findings show that melatonin and its receptors (MT1a and MT1b) are present in the inner ear, thus supporting the hypothesis that melatonin plays a physiological role in the inner ear.
影响因子：
3.4
作者：
Tosini, Gianluca;Baba, Kenkichi;Hwang, Christopher K.;Iuvone, P. Michael
通讯作者：
Iuvone, P. Michael