Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma.
Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma.
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DOI：
10.1016/j.lfs.2012.10.009
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发表时间：
2013-01-17
期刊：
影响因子：
6.1
通讯作者：
Song, B. J.
中科院分区：
文献类型：
--
作者：
Purohit, Vishnudutt;Rapaka, Rao;Kwon, Oh Sang;Song, B. J.
本报告的目的是总结酒精和烟草暴露在肝细胞癌（HCC）发展中的作用。慢性重度酒精暴露是HCC的主要危险因素，HCC是最常见的肝癌类型。酒精摄入可能通过以下途径启动或促进HCC的发展：1)乙醛- dna加合物的形成；2)细胞色素p4502e1相关活性氧（ROS）的生成、脂质过氧化、p53突变、致癌物向致癌物的转化；3)铁积累导致ROS生成，脂质过氧化，p53突变，并通过核因子- κ b （NF-kB）激活引发炎症级联；4)谷胱甘肽耗竭导致氧化应激；5) s-腺苷蛋氨酸（SAM）耗竭和相关的癌基因DNA低甲基化；6)视黄酸耗竭通过激活蛋白-1 （AP-1）的上调导致肝细胞增殖；7)通过增加内毒素从肠道到肝脏的转移，通过CD14/toll样受体-4 （TLR-4）激活库普弗细胞，氧化应激，NF-kB或早期生长反应-1（Egr-1）激活，以及炎症细胞因子和趋化因子的产生，启动炎症级联；8)肝纤维化的诱导；9)减少自然杀伤细胞的数量和/或功能。吸烟也是HCC的一个危险因素。由于存在致突变和致癌化合物，以及由于ROS的产生和内源性抗氧化剂的消耗而引起氧化应激，它可能有助于HCC的发生和促进。同时接触酒精和烟草预计会以一种附加和/或协同的方式促进HCC的发展。
The purpose of this report is to summarize the roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma (HCC). Chronic heavy alcohol exposure is a major risk factor for HCC, which is the most frequent type of liver cancer. Alcohol ingestion may initiate and or promote the development of HCC by: 1) acetaldehyde-DNA adduct formation; 2) cytochrome P4502E1-associated reactive oxygen species (ROS) generation, lipid peroxidation, p53 mutation, and conversion of pro-carcinogens to carcinogens; 3) iron accumulation that leads to ROS generation, lipid peroxidation, p53 mutation, and initiation of inflammatory cascade via nuclear factor-KappaB (NF-kB) activation; 4) glutathione depletion leading to oxidative stress; 5) s-adenosylmethionine (SAM) depletion and associated DNA hypomethylation of oncogenes ; 6) retinoic acid depletion and resultant hepatocyte proliferation via up-regulation of activator protein-1 (AP-1); 7) initiating an inflammatory cascade through increased transfer of endotoxin from intestine to liver, Kupffer cell activation via CD14/toll-like receptor-4 (TLR-4), oxidative stress, NF-kB or early growth response-1(Egr-1) activation, and generation of inflammatory cytokines and chemokines; 8) induction of liver fibrosis; and 9) decreasing the number and/or function of Natural Killer cells. Tobacco exposure is also a risk factor for HCC. It may contribute to the initiation and promotion of HCC due the presence of mutagenic and carcinogenic compounds as well as by causing oxidative stress due to generation of ROS and depletion of endogenous antioxidants. Simultaneous exposure to alcohol and tobacco is expected to promote the development of HCC in an additive and/or synergistic manner.
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影响因子：
2.3
作者：
Brooks, PJ;Theruvathu, JA
通讯作者：
Theruvathu, JA
影响因子：
25.7
作者：
Dupont, I;Lucas, D;Albano, E
通讯作者：
Albano, E
影响因子：
10.8
作者：
Barbieri, Silvia S.;Zacchi, Elena;Tremoli, Elena
通讯作者：
Tremoli, Elena
影响因子：
45.3
作者：
Altekruse, Sean F.;McGlynn, Katherine A.;Reichman, Marsha E.
通讯作者：
Reichman, Marsha E.
DOI：
10.1111/j.1749-6632.2009.03704.x
发表时间：
2009-01-01
期刊：
STEROID ENZYMES AND CANCER
影响因子：
--
作者：
Berasain, C.;Castillo, J.;Avila, M. A.
通讯作者：
Avila, M. A.