Genome-wide analyses of retrogenes derived from the human box H/ACA snoRNAs.
Genome-wide analyses of retrogenes derived from the human box H/ACA snoRNAs.
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对源自人类 H/ACA snoRNA 的逆转录基因进行全基因组分析
DOI：
10.1093/nar/gkl1086
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发表时间：
2007
影响因子：
14.9
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Luo Y;Li S
Box H/ACA snoRNA家族是一类丰富的非蛋白质编码的RNAs，在rRNAs和SnRNAs的转录后修饰中发挥重要作用。在这里，我们报告了202个来源于box H/ACA snoRNAs的序列在人类基因组中的特征。其中大多数是使用L1整合机制形成的逆转录基因。大约96%的盒H/ACA RNA相关序列位于黑猩猩和人类染色体上的相应位置，而小鼠则有50%的人类序列相同，这表明灵长类动物中的一些H/ACA RNA相关序列发生在啮齿动物/灵长类动物分化之后。在H/ACA RNA相关序列中，49%位于蛋白质编码基因的内含子区域，H/ACA相关序列可折叠为box H/ACA snoRNA家族的典型二级结构，其中30个序列被认为是其对应的box H/ACA snoRNAs的功能同源物。在具有Box H/ACA RNA家族典型二级结构的序列中，有11个序列在EST数据库中被发现，其中5个序列在多个人体组织中表达。值得注意的是，U107f嵌套在编码nudex-type基序13的蛋白质基因的一个内含子中，但从相反的链表达，EST数据库的搜索发现它可以在肝脏和脾中表达，甚至在黑色素瘤中也可以表达。
The family of box H/ACA snoRNA is an abundant class of non-protein-coding RNAs, which play important roles in the post-transcriptional modification of rRNAs and snRNAs. Here we report the characterization in the human genome of 202 sequences derived from box H/ACA snoRNAs. Most of them were retrogenes formed using the L1 integration machinery. About 96% of the box H/ACA RNA-related sequences are found in corresponding locations on the chimpanzee and human chromosomes, while the mouse shares ∼50% of these human sequences, suggesting that some of the H/ACA RNA-related sequences in primate occurred after the rodent/primate divergence. Of the H/ACA RNA-related sequences, 49% are found in intronic regions of protein-coding genes and 64 H/ACA-related sequences can be folded to the typical secondary structure of the box H/ACA snoRNA family, while 30 of them were recognized as functional homologs of their corresponding box H/ACA snoRNAs previously reported. Of the 64 sequences with the typical secondary structure of the box H/ACA RNA family, 11 were found in EST databases and 5 among which were shown to be expressed in more than one human tissue. Notably, U107f is nested in an intron of a protein gene coding for nudix-type motif 13, but expressed from the opposite strand, and the searching of EST databases revealed it can be expressed in liver and spleen, even in melanotic melanoma.
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影响因子：
4.8
作者：
Li, SG;Zhou, H;Qu, LH
通讯作者：
Qu, LH
影响因子：
10.5
作者：
Ganot, P;CaizerguesFerrer, M;Kiss, T
通讯作者：
Kiss, T
影响因子：
14.9
作者：
Perreault J;Noël JF;Brière F;Cousineau B;Lucier JF;Perreault JP;Boire G
通讯作者：
Boire G
一种新型的实验方法，用于系统地识别真核生物的盒子H/ACA snornas。
影响因子：
14.9
作者：
Gu AD;Zhou H;Yu CH;Qu LH
通讯作者：
Qu LH
影响因子：
14.9
作者：
Schattner, P;Decatur, WA;Lowe, TM
通讯作者：
Lowe, TM