Automatic contour propagation using deformable image registration to determine delivered dose to spinal cord in head-and-neck cancer radiotherapy.
Automatic contour propagation using deformable image registration to determine delivered dose to spinal cord in head-and-neck cancer radiotherapy.
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DOI：
10.1088/1361-6560/aa76aa
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发表时间：
2017-07-12
影响因子：
3.5
通讯作者：
Parker MA
中科院分区：
文献类型：
--
作者：
Yeap PL;Noble DJ;Harrison K;Bates AM;Burnet NG;Jena R;Romanchikova M;Sutcliffe MPF;Thomas SJ;Barnett GC;Benson RJ;Jefferies SJ;Parker MA
为了确定给脊髓的剂量，已经开发了一种技术，将用于治疗计划的千伏计算机断层扫描（kVCT）的手动轮廓传播到兆伏计算机断层扫描（MVCT）引导扫描。该技术使用Elastix软件对每个kVCT扫描进行基于强度的可变形图像配准到相关的MVCT扫描。然后将配准变换应用于在kVCT扫描上手动绘制的脊髓轮廓，以获得MVCT扫描上的轮廓位置。研究了不同的配准策略，并通过比较由肿瘤学家绘制的自动轮廓和手动轮廓来评估其性能。比较指标包括符合性指数（CI）和中心间距离（DBC）。通过优化配准，自动轮廓通常与手动轮廓一致。考虑所有30 MVCT扫描每三个病人,CI中值,平均DBC是()毫米。intra-observer比较同一扫描给平均CI和()毫米的DBC。好水平的一致性也得到当auto-contours与手动轮廓从一个观察者为单个MVCT扫描每个30个病人,当他们与手动轮廓从六个观察者两MVCT扫描每三个病人。一项对33名接受头颈癌放疗的患者进行的初步研究表明，使用自动轮廓来估计治疗时器官的位置，在脊髓的计划剂量和实际剂量之间存在良好的一致性。
To determine delivered dose to the spinal cord, a technique has been developed to propagate manual contours from kilovoltage computed-tomography (kVCT) scans for treatment planning to megavoltage computed-tomography (MVCT) guidance scans. The technique uses the Elastix software to perform intensity-based deformable image registration of each kVCT scan to the associated MVCT scans. The registration transform is then applied to contours of the spinal cord drawn manually on the kVCT scan, to obtain contour positions on the MVCT scans. Different registration strategies have been investigated, with performance evaluated by comparing the resulting auto-contours with manual contours, drawn by oncologists. The comparison metrics include the conformity index (CI), and the distance between centres (DBC). With optimised registration, auto-contours generally agree well with manual contours. Considering all 30 MVCT scans for each of three patients, the median CI is , and the median DBC is () mm. An intra-observer comparison for the same scans gives a median CI of and a DBC of () mm. Good levels of conformity are also obtained when auto-contours are compared with manual contours from one observer for a single MVCT scan for each of 30 patients, and when they are compared with manual contours from six observers for two MVCT scans for each of three patients. Using the auto-contours to estimate organ position at treatment time, a preliminary study of 33 patients who underwent radiotherapy for head-and-neck cancers indicates good agreement between planned and delivered dose to the spinal cord.
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