Inflammasomes and Type 1 Diabetes.
Inflammasomes and Type 1 Diabetes.
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DOI：
10.3389/fimmu.2021.686956
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发表时间：
2021
影响因子：
7.3
通讯作者：
Wen L
中科院分区：
文献类型：
--
作者：
Pearson JA;Wong FS;Wen L
在动物模型和人类中，微生物群已被确定为1型糖尿病发展中易感性的重要调节剂。总的来说，这些研究强调了微生物群组成与遗传风险，胰岛自身抗体发展和免疫反应调节的相关性。然而，参与介导这些变化的信号通路研究较少，特别是在人类中。重要的是，了解响应微生物刺激的信号通路的激活对于进一步开发免疫治疗剂至关重要，这可能增强对微生物群的耐受性或防止自身免疫过程的启动。在1型糖尿病的背景下研究较少的一种这样的信号传导途径是炎性体的作用，炎性体是多蛋白复合物，其可以在检测到其微生物配体后引发免疫应答。在这篇综述中，我们讨论了炎症小体在调节1型糖尿病易感性中的作用，从遗传关联到炎症小体的启动和激活。此外，我们还总结了现有的抑制剂，治疗靶向的炎性小体，这可能是未来使用的1型糖尿病。
Microbiota have been identified as an important modulator of susceptibility in the development of Type 1 diabetes in both animal models and humans. Collectively these studies highlight the association of the microbiota composition with genetic risk, islet autoantibody development and modulation of the immune responses. However, the signaling pathways involved in mediating these changes are less well investigated, particularly in humans. Importantly, understanding the activation of signaling pathways in response to microbial stimulation is vital to enable further development of immunotherapeutics, which may enable enhanced tolerance to the microbiota or prevent the initiation of the autoimmune process. One such signaling pathway that has been poorly studied in the context of Type 1 diabetes is the role of the inflammasomes, which are multiprotein complexes that can initiate immune responses following detection of their microbial ligands. In this review, we discuss the roles of the inflammasomes in modulating Type 1 diabetes susceptibility, from genetic associations to the priming and activation of the inflammasomes. In addition, we also summarize the available inhibitors for therapeutically targeting the inflammasomes, which may be of future use in Type 1 diabetes.
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影响因子：
7.7
作者：
Ablamunits V;Henegariu O;Hansen JB;Opare-Addo L;Preston-Hurlburt P;Santamaria P;Mandrup-Poulsen T;Herold KC
通讯作者：
Herold KC
影响因子：
56.9
作者：
Bauernfried, Stefan;Scherr, Matthias J.;Hornung, Veit
通讯作者：
Hornung, Veit
影响因子：
30.5
作者：
Buerckstuemmer, Tilmann;Baumann, Christoph;Superti-Furga, Giulio
通讯作者：
Superti-Furga, Giulio
影响因子：
7.3
作者：
Carlos D;Costa FR;Pereira CA;Rocha FA;Yaochite JN;Oliveira GG;Carneiro FS;Tostes RC;Ramos SG;Zamboni DS;Camara NO;Ryffel B;Silva JS
通讯作者：
Silva JS
影响因子：
3.7
作者：
de Groot PF;Belzer C;Aydin Ö;Levin E;Levels JH;Aalvink S;Boot F;Holleman F;van Raalte DH;Scheithauer TP;Simsek S;Schaap FG;Olde Damink SWM;Roep BO;Hoekstra JB;de Vos WM;Nieuwdorp M
通讯作者：
Nieuwdorp M