Vaccination with clumping factor A and fibronectin binding protein A to prevent Staphylococcus aureus infection of an aortic patch in mice.
Vaccination with clumping factor A and fibronectin binding protein A to prevent Staphylococcus aureus infection of an aortic patch in mice.
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DOI：
10.1086/590210
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发表时间：
2008-08-15
期刊：
影响因子：
--
通讯作者：
Lowy FD
中科院分区：
文献类型：
--
作者：
Arrecubieta C;Matsunaga I;Asai T;Naka Y;Deng MC;Lowy FD
金黄色葡萄球菌是心室辅助装置相关感染的主要原因。本研究评价了抗沙门氏菌的保护作用。金黄色葡萄球菌感染的主动和被动免疫，靶向3蛋白参与细菌附着到鼠主动脉内聚氨酯补丁。用凝集因子A（ClfA）、纤连蛋白结合蛋白A（FnBPA）和纤连蛋白结合蛋白B的A结构域的组合对小鼠进行主动免疫或用针对ClfA和FnBPA的单克隆抗体进行被动免疫导致比单独用蛋白质或抗体接种所获得的保护水平更高的保护水平。抗体或蛋白质抗原的组合似乎提供增强的保护以对抗假体装置感染。
Staphylococcus aureus is a leading cause of ventricular assist device–related infections. This study evaluated the protective effect against S. aureus infection of active and passive immunization that targeted 3 proteins involved in bacterial attachment to a murine intra-aortic polyurethane patch. Active immunization of mice with a combination of the A domains of clumping factor A (ClfA), fibronectin-binding protein A (FnBPA) and fibronectin-binding protein B or passive immunization with monoclonal antibodies against ClfA and FnBPA resulted in a higher level of protection than that obtained by vaccination with either protein or antibody alone. The combination of antibodies or protein antigens appears to provide enhanced protection against prosthetic-device infection.
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影响因子：
15.3
作者：
Que, YA;Haefliger, JA;Piroth, L;François, P;Widmer, E;Entenza, JM;Sinha, B;Herrmann, M;Francioli, P;Vaudaux, P;Moreillon, P
通讯作者：
Moreillon, P
影响因子：
6.4
作者：
Arrecubieta, C;Asai, T;Lowy, FD
通讯作者：
Lowy, FD
影响因子：
4.8
作者：
Roche, FM;Downer, R;Foster, TJ
通讯作者：
Foster, TJ
影响因子：
3.1
作者：
MOREILLON, P;ENTENZA, JM;VAUDAUX, P
通讯作者：
VAUDAUX, P
影响因子：
3.8
作者：
SCHENNINGS, T;HEIMDAHL, A;FLOCK, JI
通讯作者：
FLOCK, JI