Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis.
Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis.
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DOI：
10.1038/s41598-020-77334-1
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发表时间：
2020-11-23
影响因子：
4.6
通讯作者：
Pérez de Val B
中科院分区：
文献类型：
--
作者：
Arrieta-Villegas C;Allepuz A;Grasa M;Martín M;Cervera Z;Mercader I;López-Soria S;Domingo M;Pérez de Val B
为山羊接种结核病疫苗已被推广为控制受感染牲畜群中疾病的辅助工具。在5个山羊群中进行了为期3年的试验，以评估卡介苗的效力。在试验开始时（第0个月），使用三种不同的诊断试验检测所有动物的TB。所有试验阴性的动物接种BCG，所有替代山羊幼崽也在整个试验期间系统接种。在第6、12、24和36个月时，使用疫苗相容性试剂通过干扰素-γ释放试验（IGRA）对所有动物进行检测。结核感染的危险因素也进行了评估。在研究结束时，五分之四的农场显示初始患病率的不同程度降低（分别为93.5%、28.5%、23.2%和14.3%），在BCG接种山羊中观察到总体发病率降低50%，尽管成年接种山羊的发病率高于接种山羊的发病率。牛群中未接种疫苗的阳性动物和成年卡介苗接种山羊显著增加了接种动物的感染风险。对山羊进行系统的卡介苗接种，并清除未接种疫苗的阳性动物，可能有助于降低山羊群中的结核病流行率。
Vaccination of goats against tuberculosis (TB) has been promoted as an ancillary tool for controlling the disease in infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals were tested for TB using thee different diagnostic tests. Animals negative to all tests were vaccinated with BCG and all replacement goat kids were also systematically vaccinated throughout the trial. All animals were tested by Interferon-gamma release assay (IGRA) using vaccine compatible reagents at months 6, 12, 24, and 36. The risk factors for TB infection were also evaluated. At the end of the study, four out of five farms showed variable reductions of the initial prevalence (93.5%, 28.5%, 23.2%, and 14.3% respectively), and an overall incidence reduction of 50% was observed in BCG vaccinated goats, although adult vaccinated goats showed higher incidences than vaccinated goat kids. The unvaccinated positive animals remaining in herds and adult BCG vaccinated goats significantly enhanced the risk of infection in vaccinated animals. A systematic vaccination of goats with BCG, together with the removal of positive unvaccinated animals, may contribute to reducing the TB prevalence in goat herds.
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影响因子：
3.7
作者：
Domingo, M.;Gil, O.;Cardona, P. -J.
通讯作者：
Cardona, P. -J.
影响因子：
168.9
作者：
Black, GF;Weir, RE;Dockrell, HM
通讯作者：
Dockrell, HM
影响因子：
5.5
作者：
Elias, Daniel;Britton, Sven;Akuffo, Hannah
通讯作者：
Akuffo, Hannah
影响因子：
3.7
作者：
Gormley, Eamonn;Bhuachalla, Deirdre Ni;Corner, Leigh A. L.
通讯作者：
Corner, Leigh A. L.
影响因子：
4.3
作者：
Flynn, R. J.;Mulcahy, G.;McNair, J.
通讯作者：
McNair, J.