Re-balance of memory T cell subsets in peripheral blood from patients with CML after TKI treatment.
Re-balance of memory T cell subsets in peripheral blood from patients with CML after TKI treatment.
复制标题
TKI治疗后CML患者外周血记忆T细胞亚群的重新平衡
DOI：
10.18632/oncotarget.20965
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发表时间：
2017-10-10
期刊：
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Yao D;Xu L;Tan J;Zhang Y;Lu S;Li M;Lu S;Yang L;Chen S;Chen J;Lai J;Lu Y;Wu X;Zha X;Li Y
T细胞免疫监视被认为是抑制肿瘤发生的重要宿主保护过程。T细胞免疫监视的全部能力依赖于T细胞稳态，特别是对于中央记忆T（TCM）细胞和干细胞记忆T（TSCM）细胞。应用流式细胞仪检测了12例慢性粒细胞白血病（CML）和12例CML完全缓解期（CR）患者外周血T细胞亚群的分布，并以16例健康人（HI）为对照。CML患者外周血中CD 8 + TSCM、CD 4+和CD 8 + TCM细胞比例较HI患者低，而CD 4+效应记忆T（TEM）细胞、CD 4+和CD 8+末端效应T（TEF）细胞比例高于HI患者。CML患者的幼稚T（TN）细胞和TCM细胞亚群中具有免疫抑制功能的CD 8 + CD 28- T细胞比例较HI患者增加。我们的研究表明，通过酪氨酸激酶抑制剂（TKI）治疗消除白血病细胞可以恢复处于白血病负荷下的CML患者的记忆T细胞分布，表明由T细胞介导的白血病特异性免疫应答可能在CML患者中诱导和维持，然而，这些应答性T细胞可能由于白血病细胞及其环境的持续存在而逐渐耗尽;因此，使用不同的方法激活T细胞仍然是增强CML患者整体T细胞免疫力的关键点，即使对于那些CR状态的患者也是如此。
T cell immune surveillance is considered an important host protection process for inhibiting carcinogenesis. The full capacity of T cell immune surveillance is dependent on T cell homeostasis, particularly for central memory T (TCM) cells and stem cell memory T (TSCM) cells. In this study, distribution of T cell subsets in peripheral blood from 12 patients with chronic myeloid leukemia (CML) and 12 cases with CML in complete remission (CR) was analyzed using a multicolor flow cytometer, and 16 samples from healthy individuals (HIs) served as control. The proportion of CD8+ TSCM and CD4+ and CD8+ TCM cells were lower, while CD4+ effector memory T (TEM) cells and CD4+ and CD8+ terminal effector T (TEF) cells were higher in CML patients compared with HIs. Moreover, the proportion of CD8+CD28- T cells, which were found to have the immune suppressive function, increased in the naive T (TN) cell and TCM subsets in CML patients compared with HIs. Our study reveals that elimination of leukemia cells by treating with tyrosine kinase inhibitors (TKIs) restores the memory T cell distribution from a skewed pattern in CML patients who are under leukemia burden, indicating that leukemia-specific immune responses mediated by T cells might be induced and maintained in CML patients, however, these responsive T cells might gradually become exhausted due to the continued existence of leukemia cells and their environment; therefore, T cell activation using a different approach remains a key point for enhancing global T cell immunity in CML patients, even for those with CR status.
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影响因子：
6.5
作者：
Rouce RH;Sharma S;Huynh M;Heslop HE
通讯作者：
Heslop HE
影响因子：
28.5
作者：
Xu L;Zhang Y;Luo G;Li Y
通讯作者：
Li Y
影响因子：
3.1
作者：
Rohon, Peter;Porkka, Kimmo;Mustjoki, Satu
通讯作者：
Mustjoki, Satu
影响因子：
--
作者：
Sander FE;Rydström A;Bernson E;Kiffin R;Riise R;Aurelius J;Anderson H;Brune M;Foà R;Hellstrand K;Thorén FB;Martner A
通讯作者：
Martner A
DOI：
10.1056/nejmoa1609279
发表时间：
2016-12-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Tran E;Robbins PF;Lu YC;Prickett TD;Gartner JJ;Jia L;Pasetto A;Zheng Z;Ray S;Groh EM;Kriley IR;Rosenberg SA
通讯作者：
Rosenberg SA