The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.
The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.
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DOI：
10.1038/s41467-022-28636-7
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发表时间：
2022-02-17
影响因子：
16.6
通讯作者：
Lee SK
中科院分区：
文献类型：
--
作者：
Wang W;Cho H;Lee JW;Lee SK
How a single neuronal population diversifies into subtypes with distinct synaptic targets is a fundamental topic in neuroscience whose underlying mechanisms are unclear. Here, we show that the histone H3-lysine 27 demethylase Kdm6b regulates the diversification of motor neurons to distinct subtypes innervating different muscle targets during spinal cord development. In mouse embryonic motor neurons, Kdm6b promotes the medial motor column (MMC) and hypaxial motor column (HMC) fates while inhibiting the lateral motor column (LMC) and preganglionic motor column (PGC) identities. Our single-cell RNA-sequencing analyses reveal the heterogeneity of PGC, LMC, and MMC motor neurons. Further, our single-cell RNA-sequencing data, combined with mouse model studies, demonstrates that Kdm6b acquires cell fate specificity together with the transcription factor complex Isl1-Lhx3. Our study provides mechanistic insight into the gene regulatory network regulating neuronal cell-type diversification and defines a regulatory role of Kdm6b in the generation of motor neuron subtypes in the mouse spinal cord. Neural cell type diversification during development is a complex and highly regulated process. Here, the authors show that the histone H3-lysine 27 demethylase Kdm6b promotes and inhibits the generation of specific motor neuron subtypes during the development of the mouse spinal cord.
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影响因子：
8.8
作者：
Clovis YM;Seo SY;Kwon JS;Rhee JC;Yeo S;Lee JW;Lee S;Lee SK
通讯作者：
Lee SK
影响因子：
10.5
作者：
Agger, Karl;Cloos, Paul A. C.;Helin, Kristian
通讯作者：
Helin, Kristian
DOI：
10.1073/pnas.0707292104
发表时间：
2007-11-20
影响因子：
11.1
作者：
Hong, SunHwa;Cho, Young-Wook;Ge, Kai
通讯作者：
Ge, Kai
影响因子：
64.8
作者：
Jepsen, Kristen;Solum, Derek;Rosenfeld, Michael G.
通讯作者：
Rosenfeld, Michael G.
影响因子：
4.6
作者：
Delile, Julien;Rayon, Teresa;Sagner, Andreas
通讯作者：
Sagner, Andreas