Effects of low-dust forages on dust exposure, airway cytology, and plasma omega-3 concentrations in Thoroughbred racehorses: A randomized clinical trial.
Effects of low-dust forages on dust exposure, airway cytology, and plasma omega-3 concentrations in Thoroughbred racehorses: A randomized clinical trial.
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DOI：
10.1111/jvim.16598
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发表时间：
2023-01
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
由于暴露在粉尘中，赛马通常会出现轻度哮喘的症状。缺乏omega-3多不饱和脂肪酸(Ω-3)的饮食可能会加剧这种反应。比较饲喂干干草、蒸干干草和干草的赛马的粉尘暴露、支气管肺泡灌洗液细胞学以及血浆Ω-3和特殊分解介质浓度。43匹纯种赛马。前瞻性临床试验。马匹被随机分配到饲喂干干草、蒸干草或干草6 周。两次测量呼吸区的粉尘暴露量。分别于基线、3周、6周进行BALF细胞学检查。在基线和第6周检测血脂谱和血浆Spm浓度。广义线性混合模型检验了饲料对粉尘暴露、肺泡灌洗液细胞学、Ω-3和Spm浓度的影响。饲喂干草的马匹的呼吸性粉尘显著增加(最小二乘平均值 ± S.E.M.0.081 ± 0.007 mg/m~3)与蒸干草(0.056 ±0.005 m g/m~3，P<0.01)或干草(0.053 ± 0.005 m g/m~3，P <； .01)比较。6周时，吃干草组中性粒细胞比例(3.0% ± 0.6%)显著低于基础组(5.1 ± 0.7，P<0.01)和干草组(6.3% ±0.8%，P <； .01)。进食干草6 周的马血浆二十碳五烯酸/花生四烯酸比值(0.51 ± 0.07)显著高于基础值(0.34 ± 0.05，P <； .01)、蒸马组(0.24 ± 0.02，P <； .01)和干草组(0.25 ± 0.03，P <； .01)。与干干草相比，蒸干草和干草减少了粉尘暴露，但在6 周内，只有干草增加了抗炎/促炎脂质的比例，同时降低了中性粒细胞比例。
Racehorses commonly develop evidence of mild asthma in response to dust exposure. Diets deficient in omega‐3 polyunsaturated fatty acids (Ω‐3) might exacerbate this response. To compare dust exposure, bronchoalveolar lavage fluid (BALF) cytology, and plasma Ω‐3 and specialized pro‐resolving mediators (SPM) concentrations amongst racehorses fed dry hay, steamed hay, and haylage. Forty‐three Thoroughbred racehorses. Prospective clinical trial. Horses were randomly assigned to be fed dry hay, steamed hay, or haylage for 6 weeks. Measures of exposure to dust in the breathing zone were obtained twice. At baseline, week‐3, and week‐6, BALF cytology was examined. Plasma lipid profiles and plasma SPM concentrations were examined at baseline and week 6. Generalized linear mixed models examined the effect of forage upon dust exposure, BALF cytology, Ω‐3, and SPM concentrations. Respirable dust was significantly higher for horses fed hay (least‐square mean ± s.e.m. 0.081 ± 0.007 mg/m3) when compared with steamed hay (0.056 ± 0.005 mg/m3, P = .01) or haylage (0.053 ± 0.005 mg/m3, P < .01). At week 6, BALF neutrophil proportions in horses eating haylage (3.0% ± 0.6%) were significantly lower compared with baseline (5.1 ± 0.7, P = .04) and horses eating hay (6.3% ± 0.8%, P < .01). Plasma eicosapentaenoic acid to arachidonic acid ratios were higher in horses eating haylage for 6 weeks (0.51 ± 0.07) when compared with baseline (0.34 ± 0.05, P < .01) and horses eating steamed (0.24 ± 0.02, P < .01) or dry hay (0.25 ± 0.03, P < .01). Steamed hay and haylage reduce dust exposure compared with dry hay, but only haylage increased the ratio of anti‐inflammatory to pro‐inflammatory lipids while reducing BAL neutrophil proportions within 6 weeks.
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影响因子：
1.2
作者：
Fernandez, Nicole J.;Hecker, Kent G.;Leguillette, Renaud
通讯作者：
Leguillette, Renaud
影响因子：
2.2
作者：
Depecker, Marianne;Richard, Eric A.;Courouce-Malblanc, Anne
通讯作者：
Courouce-Malblanc, Anne
影响因子：
2.4
作者：
Clements, J. M.;Pirie, R. S.
通讯作者：
Pirie, R. S.
专门的促解决介质：感染和炎症的内源性调节剂。
DOI：
10.1038/nri.2015.4
发表时间：
2016-01
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Basil MC;Levy BD
通讯作者：
Levy BD
影响因子：
2.2
作者：
Burrell, MH;Wood, JLN;Mumford, JA
通讯作者：
Mumford, JA