RISING STARS: Mechanistic insights into maternal-fetal cross talk and islet beta-cell development.
RISING STARS: Mechanistic insights into maternal-fetal cross talk and islet beta-cell development.
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DOI：
10.1530/joe-23-0069
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发表时间：
2023-12-01
影响因子：
4
通讯作者：
Alejandro, Emilyn U.
中科院分区：
文献类型：
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作者：
Jo, Seokwon;Alejandro, Emilyn U.
个体的代谢健康轨迹早在孕前、孕期及哺乳期就已形成。母体营养状况和代谢健康状态，都是决定后代成年后罹患2型糖尿病倾向增加的关键因素。胰岛中的胰腺β细胞是对营养物质敏感的组织，对葡萄糖代谢至关重要，其在生命早期（人类生命的最初1000天）就已启动发育，且在生命后期可塑性有限。这表明子宫内及生命早期的程序化发育窗口期极为重要。本综述将聚焦于母体环境的变化如何通过改变胰腺β细胞的数量和功能，增加后代患糖尿病的易感性，并探讨胎盘介导的营养供应、激素、外泌体以及免疫改变等可能影响子宫内β细胞发育，进而影响成年后2型糖尿病易感性的潜在机制。
The metabolic health trajectory of an individual is shaped as early as prepregnancy, during pregnancy, and lactation period. Both maternal nutrition and metabolic health status are critical factors in the programming of offspring toward an increased propensity to developing type 2 diabetes in adulthood. Pancreatic beta-cells, part of the endocrine islets, which are nutrient-sensitive tissues important for glucose metabolism, are primed early in life (the first 1000 days in humans) with limited plasticity later in life. This suggests the high importance of the developmental window of programming in utero and early in life. This review will focus on how changes to the maternal milieu increase offspring’s susceptibility to diabetes through changes in pancreatic beta-cell mass and function and discuss potential mechanisms by which placental-driven nutrient availability, hormones, exosomes, and immune alterations that may impact beta-cell development in utero, thereby affecting susceptibility to type 2 diabetes in adulthood.
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影响因子：
7.7
作者：
Rachdi L;Aïello V;Duvillié B;Scharfmann R
通讯作者：
Scharfmann R
影响因子：
5.5
作者：
Rosario FJ;Pardo S;Michelsen TM;Erickson K;Moore L;Powell TL;Weintraub ST;Jansson T
通讯作者：
Jansson T
DOI：
10.3390/children8110970
发表时间：
2021-10-26
期刊：
Children (Basel, Switzerland)
影响因子：
--
作者：
Beetch M;Alejandro EU
通讯作者：
Alejandro EU
影响因子：
3.7
作者：
Sisino G;Zhou AX;Dahr N;Sabirsh A;Soundarapandian MM;Perera R;Larsson-Lekholm E;Magnone MC;Althage M;Tyrberg B
通讯作者：
Tyrberg B
影响因子：
4.6
作者：
通讯作者：
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