Systematic confirmation study of GWAS-identified genetic variants for Kawasaki disease in a Chinese population.
Systematic confirmation study of GWAS-identified genetic variants for Kawasaki disease in a Chinese population.
复制标题
GWAS 鉴定的中国人群川崎病遗传变异的系统证实研究
DOI：
10.1038/srep08194
复制
发表时间：
2015-02-03
影响因子：
4.6
通讯作者：
Miao XP
中科院分区：
文献类型：
--
作者：
Lou J;Zhong R;Shen N;Lu XZ;Ke JT;Duan JY;Qi YQ;Wang YJ;Zhang Q;Wang W;Gong FQ;Miao XP
全基因组关联研究（GWASs）已经确定了与川崎病（KD）相关的多个单核苷酸多态性（snp）。在这项研究中，我们在中国汉族人群中重复了10个gwas鉴定的snp与KD的关联。通过logistic回归计算优势比（ORs）和95%置信区间（CIs），并计算非危险基因型的累积效应。虽然没有一个snp达到校正的显著性水平，但有4个snp显示与KD风险有名义上的关联。与野生型相比，rs1801274 AG+GG基因型和rs3818298 TC+CC基因型名义上与KD风险降低相关（OR = 0.77, 95% CI = 0.59-0.99，P= 0.045; OR = 0.74, 95% CI = 0.56-0.98，P= 0.038）。同时，rs1801274 GG基因型、rs2736340 CC基因型和rs4813003 TT基因型与rs1801274 AG+AA基因型、rs2736340 CT+TT基因型和rs4813003 TC+CC基因型相比，分别有降低风险的趋势（or = 0.57, 95% CI = 0.35 ~ 0.93，P= 0.024; or = 0.46, 95% CI = 0.26 ~ 0.83，P= 0.010; or = 0.64, 95% CI = 0.43 ~ 0.94，P= 0.022）。此外，观察到累积效应，随着非危险基因型累积数量的增加，or逐渐降低（p趋势<0.001）。总之，我们的研究表明，gwas鉴定的4个snp， rs2736340, rs4813003， rs3818298和rs1801274，在中国汉族人群中单独或共同与KD风险相关。
Genome-wide association studies (GWASs) have identified multiple single nucleotide polymorphisms (SNPs) associated with Kawasaki disease (KD). In this study, we replicated the associations of 10 GWAS-identified SNPs with KD in a Han Chinese population. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression and cumulative effect of non-risk genotypes were also performed. Although none of the SNPs reached the corrected significance level, 4 SNPs showed nominal associations with KD risk. Compared with their respective wild type counterparts, rs1801274 AG+GG genotypes and rs3818298 TC+CC genotypes were nominally associated with the reduced risk of KD (OR = 0.77, 95% CI = 0.59–0.99,P= 0.045; OR = 0.74, 95% CI = 0.56–0.98,P= 0.038). Meanwhile, rs1801274 GG genotype, rs2736340 CC genotype or rs4813003 TT genotype showed a reduced risk trend (OR = 0.57, 95% CI = 0.35–0.93,P= 0.024; OR = 0.46, 95% CI = 0.26–0.83,P= 0.010; OR = 0.64, 95% CI = 0.43–0.94,P= 0.022), compared with rs1801274 AG+AA genotypes, rs2736340 CT+TT genotypes or rs4813003 TC+CC genotypes, respectively. Furthermore, a cumulative effect was observed with the ORs being gradually decreased with the increasing accumulative number of non-risk genotypes (Ptrend<0.001). In conclusion, our study suggests that 4 GWAS-identified SNPs, rs2736340, rs4813003, rs3818298 and rs1801274, were nominally associated with KD risk in a Han Chinese population individually and jointly.
登录
查看更多内容
影响因子：
3.7
作者：
Chang CJ;Kuo HC;Chang JS;Lee JK;Tsai FJ;Khor CC;Chang LC;Chen SP;Ko TM;Liu YM;Chen YJ;Hong YM;Jang GY;Hibberd ML;Kuijpers T;Burgner D;Levin M;Burns JC;Davila S;International Kawasaki Disease Genetics Consortium;Korean Kawasaki Disease Genetics Consortium;Taiwan Kawasaki Disease Genetics Consortium;Chen YT;Chen CH;Wu JY;Lee YC
通讯作者：
Lee YC
影响因子：
5
作者：
LUBIN, JH;GAIL, MH
通讯作者：
GAIL, MH
影响因子：
5.3
作者：
Kim, Jae-Jung;Hong, Young Mi;Lee, Jong-Keuk
通讯作者：
Lee, Jong-Keuk
影响因子：
4.5
作者：
Burgner D;Davila S;Breunis WB;Ng SB;Li Y;Bonnard C;Ling L;Wright VJ;Thalamuthu A;Odam M;Shimizu C;Burns JC;Levin M;Kuijpers TW;Hibberd ML;International Kawasaki Disease Genetics Consortium
通讯作者：
International Kawasaki Disease Genetics Consortium
影响因子：
30.8
作者：
Gregersen, Peter K.;Amos, Chistopher I.;Lee, Annette T.;Lu, Yue;Remmers, Elaine F.;Kastner, Daniel L.;Seldin, Michael F.;Criswell, Lindsey A.;Plenge, Robert M.;Holers, V. Michael;Mikuls, Ted R.;Sokka, Tuulikki;Moreland, Larry W.;Bridges, S. Louis, Jr.;Xie, Gang;Begovich, Ann B.;Siminovitch, Katherine A.
通讯作者：
Siminovitch, Katherine A.