REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
复制标题
DOI：
10.1038/ng.395
复制
发表时间：
2009-07
期刊：
影响因子：
30.8
通讯作者：
Siminovitch, Katherine A.
中科院分区：
文献类型：
--
作者：
Gregersen, Peter K.;Amos, Chistopher I.;Lee, Annette T.;Lu, Yue;Remmers, Elaine F.;Kastner, Daniel L.;Seldin, Michael F.;Criswell, Lindsey A.;Plenge, Robert M.;Holers, V. Michael;Mikuls, Ted R.;Sokka, Tuulikki;Moreland, Larry W.;Bridges, S. Louis, Jr.;Xie, Gang;Begovich, Ann B.;Siminovitch, Katherine A.
“”
We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and 4,504 controls from North America and identified an association at theRELlocus, encoding c-Rel, on chromosome 2p13 (rs13031237,P= 6.01 × 10−10). Replication in independent case-control datasets comprising 2,604 cases and 2,882 controls confirmed this association, yielding an allelic OR = 1.25 (P= 3.08 × 10−14) for marker rs13031237 and an allelic OR = 1.21 (P= 2.60 × 10−11) for marker rs13017599 in the combined dataset. The combined dataset also provides definitive support for associations at bothCTLA4(rs231735; OR = 0.85;P= 6.25 × 10−9) andBLK(rs2736340; OR = 1.19;P= 5.69 × 10−9). c-Rel is an NF-κB family member with distinct functional properties in hematopoietic cells, and its association with rheumatoid arthritis suggests disease pathways that involve other recently identified rheumatoid arthritis susceptibility genes includingCD40,TRAF1,TNFAIP3andPRKCQ,.
登录
查看更多内容
影响因子：
--
作者：
Ding, Bo;Padyukov, Leonid;Lundstrom, Emeli;Seielstad, Mark;Plenge, Robert M.;Oksenberg, Jorge R.;Gregersen, Peter K.;Alfredsson, Lars;Klareskog, Lars
通讯作者：
Klareskog, Lars
影响因子：
158.5
作者：
Plenge, Robert M.;Seielstad, Mark;Gregersen, Peter K.
通讯作者：
Gregersen, Peter K.
影响因子：
30.8
作者：
Barton A;Thomson W;Ke X;Eyre S;Hinks A;Bowes J;Plant D;Gibbons LJ;Wellcome Trust Case Control Consortium;YEAR Consortium;BIRAC Consortium;Wilson AG;Bax DE;Morgan AW;Emery P;Steer S;Hocking L;Reid DM;Wordsworth P;Harrison P;Worthington J
通讯作者：
Worthington J
影响因子：
3.5
作者：
Toubi, E;Shoenfeld, Y
通讯作者：
Shoenfeld, Y
DOI：
10.1093/jurban/jth116
发表时间：
2004-06-01
影响因子：
6.6
作者：
Mitchell, MK;Gregersen, PK;Vlahov, D
通讯作者：
Vlahov, D