Microglial dysfunction in brain aging and Alzheimer's disease.
Microglial dysfunction in brain aging and Alzheimer's disease.
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DOI：
10.1016/j.bcp.2014.01.008
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发表时间：
2014-04-15
影响因子：
5.8
通讯作者：
Wyss-Coray, Tony
中科院分区：
文献类型：
--
作者：
Mosher, Kira Irving;Wyss-Coray, Tony
小胶质细胞是中枢神经系统的免疫细胞，由于其对阿尔茨海默病（AD）的病理生理学的显著反应，长期以来一直是阿尔茨海默病（AD）领域的研究对象。随着过去一年中几项大规模遗传研究表明小胶质细胞分子与AD有关，这些细胞的潜在意义比以往任何时候都更加突出。作为一种与衰老密切相关的疾病，AD大脑的小胶质细胞与衰老的小胶质细胞有一些共同的表型也许并不完全令人惊讶。然而，这两种情况对小胶质细胞的相对影响很少被一致考虑。此外，小胶质细胞“激活”和“神经炎症”通常在神经变性的研究中进行分析，但实际上是包含多个细胞过程的一些定义不清的概念。在这篇综述中，我们列举了小胶质细胞的六种不同功能，并讨论了衰老和AD的具体影响。通过关注这两种状态的共同点，我们希望激发新的方法来解剖小胶质细胞机制。
Microglia, the immune cells of the central nervous system, have long been a subject of study in the Alzheimer’s disease (AD) field due to their dramatic responses to the pathophysiology of the disease. With several large-scale genetic studies in the past year implicating microglial molecules in AD, the potential significance of these cells has become more prominent than ever before. As a disease that is tightly linked to aging, it is perhaps not entirely surprising that microglia of the AD brain share some phenotypes with aging microglia. Yet the relative impacts of both conditions on microglia are less frequently considered in concert. Furthermore, microglial “activation” and “neuroinflammation” are commonly analyzed in studies of neurodegeneration but are somewhat ill-defined concepts that in fact encompass multiple cellular processes. In this review, we have enumerated six distinct functions of microglia and discuss the specific effects of both aging and AD. By calling attention to the commonalities of these two states, we hope to inspire new approaches for dissecting microglial mechanisms.
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影响因子：
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影响因子：
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