HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer.
HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer.
复制标题
DOI：
10.1038/bjc.2017.220
复制
发表时间：
2017-08-08
影响因子：
8.8
通讯作者：
Amir E
中科院分区：
文献类型：
--
作者：
Barnes TA;Amir E
几十年来，免疫细胞和恶性细胞之间的相互作用已经被认为具有临床意义。免疫控制的潜力现在正在通过检查点抑制剂和其他新型药物来改善癌症的治疗效果。免疫浸润作为预后标志物的重要性越来越重要。在这篇小综述中，我们概述了免疫浸润及其空间组织，并总结了免疫细胞在不同癌症类型中的预后价值。国际合作正在标准化免疫浸润的组织病理学报告，以允许在临床和研究环境中应用这些参数。一般而言，“促炎性”肿瘤微环境和浸润性表达CD8的T淋巴细胞与广泛肿瘤类型的临床结局改善相关。其他免疫细胞的抑制功能，例如，骨髓来源的抑制细胞和调节性T细胞，似乎在破坏癌症的免疫控制能力方面具有主要作用。
Interactions between immune and malignant cells have been known to have clinical relevance for decades. The potential for immune control is now being therapeutically enhanced with checkpoint inhibitors and other novel agents to improve outcomes in cancer. The importance of the immune infiltrate as a prognostic marker is increasingly relevant. In this minireview, we present an overview of the immune infiltrate and its spatial organisation, and summarise the prognostic value of immune cells in different cancer types. International collaborative efforts are standardising histopathologic reporting of the immune infiltrate, to allow application of these parameters in the clinical and research settings. In general terms, a ‘pro-inflammatory’ tumour microenvironment and infiltrating CD8-expressing T lymphocytes are associated with improved clinical outcomes in a broad range of tumour types. The inhibitory function of other immune cells, for example, myeloid-derived suppressor cells and regulatory T cells, appear to have a major role in disrupting the capacity for the immune control of cancers.
登录
查看更多内容
影响因子：
8.8
作者：
Balermpas, P;Michel, Y;Wagenblast, J;Seitz, O;Weiss, C;Rodel, F;Rodel, C;Fokas, E
通讯作者：
Fokas, E
影响因子：
45.3
作者：
Adams, Sylvia;Gray, Robert J.;Badve, Sunil S.
通讯作者：
Badve, Sunil S.
影响因子：
11.5
作者：
Badoual, C;Hans, S;Tartour, E
通讯作者：
Tartour, E
影响因子：
2.2
作者：
Fortes, Cristina;Mastroeni, Simona;Michelozzi, Paola
通讯作者：
Michelozzi, Paola
影响因子：
10.1
作者：
Gabrielson A;Wu Y;Wang H;Jiang J;Kallakury B;Gatalica Z;Reddy S;Kleiner D;Fishbein T;Johnson L;Island E;Satoskar R;Banovac F;Jha R;Kachhela J;Feng P;Zhang T;Tesfaye A;Prins P;Loffredo C;Marshall J;Weiner L;Atkins M;He AR
通讯作者：
He AR