A new staging system for nasopharyngeal carcinoma based on intensity-modulated radiation therapy (IMRT).
A new staging system for nasopharyngeal carcinoma based on intensity-modulated radiation therapy (IMRT).
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基于调强放射治疗（IMRT）的鼻咽癌新分期系统。
DOI：
10.18632/oncotarget.21615
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发表时间：
2017-11-07
期刊：
影响因子：
--
通讯作者：
Wang R
中科院分区：
文献类型：
--
作者：
Kang M;Zhou P;Long J;Li G;Yan H;Feng G;Liu M;Zhu J;Wang R
本研究旨在建立一种基于MRI和调强放射治疗（IMRT）的鼻咽癌（NPC）分期系统。共纳入492例鼻咽癌患者。这些患者均经病理检查确诊（无远处转移），并接受调强放疗的初始治疗。采用国际抗癌联盟/美国癌症联合委员会（UICC/AJCC）分期系统对患者进行分期。采用Kaplan-Meier法计算生存率。单因素预后采用Log-rank检验，多因素预后采用考克斯风险模型分析。在这492例患者中，根据我们推荐的新T和N分期标准，T1有290例，T2有202例; N 0有64例，N1有159例，N2有226例，N3有43例。单因素和多因素分析显示T、N分期组合参数是影响总生存率和无瘤生存率的独立预后因素。根据风险差异和生存曲线分布建立了以下新的临床分期标准：I期（T1 N 0 M0）、II期（T1 N1 M0和T2 N 0 M0）、III期（T1 N2 M0和T2 N1 - 2 M0）、IVa期（T1- 2N 3 M0）和IVb期（TxNxM 1）。提出了一种基于MRI和IMRT的鼻咽癌分期新方法，为鼻咽癌的治疗和预后判断提供了有价值的依据。
This study is to establish a new staging system for nasopharyngeal carcinoma (NPC) based on the magnetic resonance imaging (MRI) and intensity-modulated radiation therapy (IMRT). Totally 492 patients with nasopharyngeal carcinoma were included in this study. These patients were diagnosed by pathological detection (without distant metastasis) and underwent the initial treatment of IMRT. These patients were subjected to the staging with the International Union against Cancer/American Joint Committee on Cancer (UICC/AJCC) staging system. Survival rates were calculated by the Kaplan-Meier method. Log-rank test was used to calculate the single factor prognosis, and the COX risk model was used to analyze the multivariate prognosis. In these 492 patients, according to our recommended new T and N staging criteria, there were 290 cases of T1 and 202 cases of T2; there were 64 cases of N0, 159 cases of N1, 226 cases of N2, and 43 cases of N3. Univariate and multivariate analyses showed that the T and N staging combination parameters were independent prognostic factors, which affected the overall survival rates and tumor-free survival rates. According to risk difference and survival curve distribution, the following new clinical staging criteria were established: stage I (T1N0M0), stage II (T1N1M0 and T2N0M0), stage III (T1N2M0 and T2N1-2M0), stage IVa (T1-2N3M0), and stage IVb (TxNxM1). A new staging system for NPC based on MRI and IMRT has been recommended, which provides valuable evidence for disease treatment and prognosis prediction.
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影响因子：
4.8
作者：
Sze, Henry;Chan, Lucy L. K.;Lee, Anne W. M.
通讯作者：
Lee, Anne W. M.
DOI：
10.1016/j.ijrobp.2008.03.017
发表时间：
2008-12-01
影响因子：
7
作者：
Liao, Xin-Biao;Mao, Yan-Ping;Ma, Jun
通讯作者：
Ma, Jun
磁共振波谱检查对鼻咽癌放疗所致放射性脑病诊断价值的Meta分析
影响因子：
--
作者：
Chen WS;Li JJ;Hong L;Xing ZB;Wang F;Li CQ
通讯作者：
Li CQ
DOI：
10.1016/j.ijrobp.2012.09.003
发表时间：
2013-06-01
影响因子：
7
作者：
Li, Wen-Fei;Sun, Ying;Ma, Jun
通讯作者：
Ma, Jun
DOI：
10.1186/s13014-015-0513-6
发表时间：
2015-09-25
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Xiao Y;Pan J;Chen Y;Lin S;Chen Y;Zong J;Fang Y;Guo Q;Chen B;Tang L
通讯作者：
Tang L