Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis.
Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis.
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磁共振波谱检查对鼻咽癌放疗所致放射性脑病诊断价值的Meta分析
DOI：
10.1155/2016/5126074
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发表时间：
2016
影响因子：
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通讯作者：
Li CQ
中科院分区：
文献类型：
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作者：
Chen WS;Li JJ;Hong L;Xing ZB;Wang F;Li CQ
本研究从2014年9月以前的电子数据库中选取了英文和中文的文章。应用质子磁共振波谱技术，提取放射治疗所致放射性脑病患者脑组织中N-乙酰天冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)、NAA/Cr、NAA/Cho、Cho/Cr的代谢浓度和代谢模式。运用荟萃分析对这些研究的结果进行量化综合。采用随机或固定有效模型计算加权平均差(WMD)和95%可信区间(95%CI)。采用Cochrane q检验和I2统计对研究间的异质性进行评估。结果表明，共有4项研究，涉及214名患者，符合纳入标准。根据选定研究的方法，对照组被称为健康受试者。联合分析显示，放疗组与健康对照组的肌酸值无显著差异(WMD=−1.483，95%CI：−67.185~64.219，p=0.965)。而NAA(WMD=−18.227，95%CI：−36.317~−0.137，P=0.048)、CHO(WMD=38.003，95%CI：5.155~70.851，P=0.023)、NAA/Cr(WMD=−1.175，95%CI：−1.563~−0.787，P=0.000)、NAA/CHO(WMD=−1.108，95%CI：−2.003~0.213，P=0.023)，Cho/Cr(WMD=−0.773，95%CI：0.239~1.307，p=0.005)。结论：MRS可作为鼻咽癌放疗后放射性脑病的一种有效、可行的影像检查方法。
In this study, articles in English and Chinese were selected from available electronic databases prior to September 2014. The metabolic concentrations and patterns of N-acetylaspartic acid (NAA), Choline (Cho), Creatine (Cr), NAA/Cr, NAA/Cho, and Cho/Cr ratios in radiotherapy-induced radiation encephalopathy by proton magnetic resonance spectroscopy were extracted. A meta-analysis was performed to quantitatively synthesize findings of these studies. Weighted mean difference (WMD) and 95% confidence intervals (95%CIs) were calculated using random or fixed effective models. Heterogeneity between studies was assessed using the Cochrane Q test and I 2 statistics. The results indicated that a total of 4 researches involving 214 patients met inclusion criteria. Depending on methodologies of selected studies, control groups were referred to as healthy subjects. The combined analysis revealed that there was no significant difference in value of Cr between radiotherapy group and healthy control group (WMD = −1.483, 95% CI: −67.185–64.219, p = 0.965). However, there were significant difference in values of NAA (WMD = −18.227, 95%CI: −36.317–−0.137, p = 0.048), Cho (WMD = 38.003, 95%CI: 5.155–70.851, p = 0.023), NAA/Cr (WMD = −1.175, 95%CI: −1.563–−0.787, p = 0.000), NAA/Cho (WMD = −1.108, 95%CI: −2.003–0.213, p = 0.015), and Cho/Cr (WMD = −0.773, 95%CI: 0.239–1.307, p = 0.005). In conclusion, MRS can be regarded as an effective and feasible imaging test for radiotherapy-induced radiation encephalopathy in NPC patients.
影响因子：
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作者：
Wu JM;Yu TJ;Yeh SA;Chao PJ;Huang CJ;Lee TF
通讯作者：
Lee TF