Review of Experimental Studies to Improve Radiotherapy Response in Bladder Cancer: Comments and Perspectives.
Review of Experimental Studies to Improve Radiotherapy Response in Bladder Cancer: Comments and Perspectives.
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DOI：
10.3390/cancers13010087
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发表时间：
2020-12-30
期刊：
影响因子：
5.2
通讯作者：
Verrelle P
中科院分区：
文献类型：
--
作者：
Silina L;Maksut F;Bernard-Pierrot I;Radvanyi F;Créhange G;Mégnin-Chanet F;Verrelle P
膀胱癌是一个主要的全球性健康问题。膀胱切除手术是肌层浸润性膀胱癌（占所有膀胱癌的25%）的标准治疗方法，但这种治疗对生活质量有负面影响，特别是对老年和体弱患者。肿瘤切除后联合放疗和化疗已成为一种有前途的膀胱保留策略。然而，这种策略无法避免与放射相关的膀胱副作用。因此，发现新的放射增敏肿瘤的同时保留正常膀胱组织的策略是非常有趣的。本文对放射增敏治疗膀胱癌的实验研究进行了综述，并提出了改进建议。膀胱癌是世界上十大最常见的癌症类型之一。大约25%的病例是肌肉浸润性膀胱癌，在没有转移的情况下，其金标准治疗是cytokine。近年来，联合最大经尿道电切术和放射治疗与同期化疗的三联治疗越来越多地被用作保留器官的替代方案。然而，这种治疗的使用仍然受到缺乏预测肿瘤反应的生物标志物和缺乏可以提高治疗指数的靶向放射增敏药物的限制，特别是通过限制副作用如膀胱纤维化。为了改善膀胱保留治疗，应考虑解决这些主要问题的实验研究（体外和体内研究）。根据系统性综述和荟萃分析的首选报告项目（PRISMA）系统性综述指南，我们在PubMed中进行了一项文献检索，研究如何使用综合检索字符串改善不同放射增敏剂的膀胱癌放射治疗。我们对实验模型选择、实验设计和结果进行了评论，阐述了仍然存在的知识差距：例如缺乏根据分子肿瘤亚型的肿瘤对化疗反应的可靠预测生物标志物，以及缺乏专门针对肿瘤的有效放射增敏剂。膀胱肿瘤细胞。我们提供了指导，以改善即将进行的研究，例如考虑到临床前模型的分子特征，并强调了使用患者来源的异种移植物以及同基因模型的价值。最后，这篇综述可能是一个有用的工具，以建立新的放射为基础的综合治疗，改善治疗指数，是膀胱保护所需的。
Bladder cancer is a major global health problem. Bladder removal surgery is the standard treatment for muscle-invasive bladder cancer (25% of all bladder cancer), but this treatment negatively affects the quality of life, especially for elderly and frail patients. Tumour resection followed by combination of radiotherapy and chemotherapy has emerged as a promising bladder preserving strategy. However, this strategy is unable to avoid radiation-related bladder side effects. Therefore, it is of great interest to discover novel strategies radiosensitising tumours while sparing normal bladder tissue. In this review, we analysed the experimental studies of radiosensitising strategies in bladder cancer and provided suggestions to improve forthcoming studies. Bladder cancer is among the top ten most common cancer types in the world. Around 25% of all cases are muscle-invasive bladder cancer, for which the gold standard treatment in the absence of metastasis is the cystectomy. In recent years, trimodality treatment associating maximal transurethral resection and radiotherapy combined with concurrent chemotherapy is increasingly used as an organ-preserving alternative. However, the use of this treatment is still limited by the lack of biomarkers predicting tumour response and by a lack of targeted radiosensitising drugs that can improve the therapeutic index, especially by limiting side effects such as bladder fibrosis. In order to improve the bladder-preserving treatment, experimental studies addressing these main issues ought to be considered (both in vitro and in vivo studies). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews, we conducted a literature search in PubMed on experimental studies investigating how to improve bladder cancer radiotherapy with different radiosensitising agents using a comprehensive search string. We made comments on experimental model selection, experimental design and results, formulating the gaps of knowledge still existing: such as the lack of reliable predictive biomarkers of tumour response to chemoradiation according to the molecular tumour subtype and lack of efficient radiosensitising agents specifically targeting bladder tumour cells. We provided guidance to improve forthcoming studies, such as taking into account molecular characteristics of the preclinical models and highlighted the value of using patient-derived xenografts as well as syngeneic models. Finally, this review could be a useful tool to set up new radiation-based combined treatments with an improved therapeutic index that is needed for bladder preservation.
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影响因子：
11.2
作者：
Choudhury A;Nelson LD;Teo MT;Chilka S;Bhattarai S;Johnston CF;Elliott F;Lowery J;Taylor CF;Churchman M;Bentley J;Knowles MA;Harnden P;Bristow RG;Bishop DT;Kiltie AE
通讯作者：
Kiltie AE
通过辐射和靶向AXL重新编程免疫学微环境。
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
5.7
作者：
Caffo, Orazio;Thompson, Catherine;Choudhury, Ananya
通讯作者：
Choudhury, Ananya
影响因子：
3.4
作者：
Cromheecke, M;Piers, BA;Hoekstra, HJ
通讯作者：
Hoekstra, HJ
影响因子：
158.5
作者：
Bonner, JA;Harari, PM;Ang, KK
通讯作者：
Ang, KK