Temporal Dynamics of Anti-Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019.

Temporal Dynamics of Anti-Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019.
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DOI:
10.1093/cid/ciab1002
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发表时间:
2022-08-24
期刊:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子:
--
通讯作者:
Su HC
Su HC
中科院分区:
其他
文献类型:
--
作者:
Shaw ER;Rosen LB;Cheng A;Dobbs K;Delmonte OM;Ferré EMN;Schmitt MM;Imberti L;Quaresima V;Lionakis MS;Notarangelo LD;Holland SM;Su HC

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抗1型干扰素自身抗体的结合水平和中和活性在2019年急性冠状病毒病期间达到峰值,此后显著下降。尽管结合免疫球蛋白G水平较低,但大多数患者仍保持一定的中和1型干扰素的能力。在严重病毒性疾病发展之前,在健康个体中识别这些自身抗体可能具有挑战性。
Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.
危及生命的Covid-19患者中针对I型IFN的自身抗体。
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