Intraneural microstimulation in humans.
Intraneural microstimulation in humans.
复制标题
DOI：
10.1016/j.neulet.2009.10.007
复制
发表时间：
2010-02-19
影响因子：
2.5
通讯作者：
Ochoa JL
中科院分区：
文献类型：
--
作者：
Ochoa JL
神经内微刺激(INMS)是由Torebjörk和Ochoa[20]以及Vallbo[23]独立开发的。作为先驱者，我们经常想知道，这种方法用于识别人类受试者纯粹被唤起的感觉的主观属性，其令人惊叹的结果是否已经是海市蜃楼。文化虚无主义抵制这样的命题，即来自人类手皮肤的某些单一感觉单位通常能够唤起具有特定和一致的主观性质、可测量的大小和可绘制位置的有意识的感觉。但是，当然，根据在给定的神经内部位附近普遍存在的物理环境，电极尖端可以记录到从零到多个神经纤维的任何地方，通常是几个。为什么连一根光纤都不录下来呢？从同一神经内微电极位置可以记录到零到多个纤维的通常情况，当然不否认也可能在刺激强度下微刺激一个神经束的零个、几个或整个纤维含量逐渐增加。为什么不刺激一根纤维呢？事实上，接受单纤维刺激的可行性比强制多纤维刺激更有可能，因为刺激强度达到了第一次可检测到的感觉的阈值。因此，经过时间的测试，我们相信有可能通过神经内微刺激来兴奋人类的单一感觉神经纤维[10，15，17，18]。如今，没有人做神经内微刺激(INMS)。这是非常苛刻的。
Intraneural microstimulation (INMS) was developed independently by Torebjörk and Ochoa [20] and by Vallbo [23]. As pioneers, we often wonder whether the awesome yield of the method, as applied to discern subjective attributes of pure evoked sensations in human subjects, has been a mirage. Cultural nihilism resists the proposition that certain single sensory units from skin of the human hand may normally be able to evoke a conscious sensation endowed with specific and consistent subjective quality, measurable magnitude, and chartable location. But, of course, depending on the physical circumstances prevailing in the neighborhood of a given intraneural site, an electrode tip can regularly record anywhere from between zero and multiple nerve fibers, and usually a few. And why not even record one single fiber in focus? The usual situation in which zero to multiple fibers are recordable from the same intra-neural microelectrode site, certainly does not negate that it may be possible also to microstimulate zero, a few, or the whole fiber content of a fascicle at stimulus intensity is gradually increased. And why not even stimulate one single fiber? Indeed, it is more plausible to accept viability of single fiber stimulation than mandatory multi-fiber stimulation at stimulus intensity at threshold for the first detectable sensation. Therefore, after the test of time, we do believe it is possible to excite single sensory nerve fibers through intra-neural microstimulation in humans [10, 15, 17, 18]. Nobody does intraneural microstimulation (INMS) these days. It is extremely demanding.
登录
查看更多内容
DOI：
10.1111/j.1748-1716.1983.tb07338.x
发表时间：
1983-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
SCHADY, WJL;TOREBJORK, HE;OCHOA, JL
通讯作者：
OCHOA, JL
影响因子：
14.5
作者：
Foerster, O
通讯作者：
Foerster, O
影响因子：
14.5
作者：
OCHOA, JL;TOREBJORK, HE
通讯作者：
TOREBJORK, HE
影响因子：
7.4
作者：
OCHOA, JL;YARNITSKY, D;CLINE, M
通讯作者：
CLINE, M
影响因子：
14.5
作者：
MELZACK, R;WALL, PD
通讯作者：
WALL, PD