Sequential fear generalization and network connectivity in trauma exposed humans with and without psychopathology.
Sequential fear generalization and network connectivity in trauma exposed humans with and without psychopathology.
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DOI：
10.1038/s42003-022-04228-5
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发表时间：
2022-11-21
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然已知受损的恐惧泛化是一系列精神病理学的基础，但暴露于创伤本身导致恐惧泛化不足及其神经异常的程度尚待研究。同样，在遭受创伤且没有发展出显著精神病理学的人中，完整的恐惧概括的神经功能还有待表征。在这里，我们利用泛化功能磁共振成像任务，和网络连接的方法来澄清假定的行为和创伤和恢复力的神经标记。泛化任务使威胁辨别学习的纵向评估成为可能。与健康对照组（HC; N = 26）相比，创伤暴露参与者（TE; N = 62）在两个连续的泛化阶段中显示出显著性网络（SN）和右执行控制网络（RECN）的活动减少较低，并且通过线性偏差评分（LDS）测量SN的辨别学习较差。比较弹性，创伤暴露的健康对照参与者（TEHC; N = 31），创伤暴露的个人提出的精神病理学（TEPG; N = 31），和HC，揭示了一个弹性签名的网络连接的差异，在RECN在LDS测量的泛化学习。这些发现可能表明创伤暴露表型有可能通过靶向和参与不同精神病理学的创伤暴露个体中的特定神经功能障碍来促进创新治疗的发展。比较有弹性的，创伤暴露的健康参与者和创伤暴露的个人提出的精神病理学揭示了一个弹性网络连接签名在正确的执行控制网络在泛化学习。
While impaired fear generalization is known to underlie a wide range of psychopathology, the extent to which exposure to trauma by itself results in deficient fear generalization and its neural abnormalities is yet to be studied. Similarly, the neural function of intact fear generalization in people who endured trauma and did not develop significant psychopathology is yet to be characterized. Here, we utilize a generalization fMRI task, and a network connectivity approach to clarify putative behavioral and neural markers of trauma and resilience. The generalization task enables longitudinal assessments of threat discrimination learning. Trauma-exposed participants (TE; N = 62), compared to healthy controls (HC; N = 26), show lower activity reduction in salience network (SN) and right executive control network (RECN) across the two sequential generalization stages, and worse discrimination learning in SN measured by linear deviation scores (LDS). Comparison of resilient, trauma-exposed healthy control participants (TEHC; N = 31), trauma exposed individuals presenting with psychopathology (TEPG; N = 31), and HC, reveals a resilience signature of network connectivity differences in the RECN during generalization learning measured by LDS. These findings may indicate a trauma exposure phenotype that has the potential to advance the development of innovative treatments by targeting and engaging specific neural dysfunction among trauma-exposed individuals, across different psychopathologies. Comparison of resilient, trauma-exposed healthy participants and trauma-exposed individuals presenting with psychopathology reveals a resilience network connectivity signature in the right executive control network during generalization learning.
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影响因子：
6.9
作者：
Berg, Hannah;Ma, Yizhou;Rueter, Amanda;Kaczkurkin, Antonia;Burton, Philip C.;DeYoung, Colin G.;MacDonald, Angus W., III;Sponheim, Scott R.;Lissek, Shmuel M.
通讯作者：
Lissek, Shmuel M.
影响因子：
7.6
作者：
Cooper, Samuel E.;van Dis, Eva A. M.;Dunsmoor, Joseph E.
通讯作者：
Dunsmoor, Joseph E.
DOI：
10.1176/appi.ajp.2009.09030410
发表时间：
2010-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Lissek S;Rabin S;Heller RE;Lukenbaugh D;Geraci M;Pine DS;Grillon C
通讯作者：
Grillon C
影响因子：
158.5
作者：
HELZER, JE;ROBINS, LN;MCEVOY, L
通讯作者：
MCEVOY, L
前扣带皮层到腹侧海马回路介导情境恐惧泛化
影响因子：
5.3
作者：
Bian, Xin-Lan;Qin, Cheng;Zhu, Dong-Ya
通讯作者：
Zhu, Dong-Ya