Overgeneralization of conditioned fear as a pathogenic marker of panic disorder.
Overgeneralization of conditioned fear as a pathogenic marker of panic disorder.
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DOI：
10.1176/appi.ajp.2009.09030410
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Grillon C
中科院分区：
文献类型：
--
作者：
Lissek S;Rabin S;Heller RE;Lukenbaugh D;Geraci M;Pine DS;Grillon C
经典条件反射在许多惊恐障碍的病因学解释中占有显著地位。根据这样的解释，在惊恐发作期间出现的中性条件刺激获得了致惊恐的特性。触发恐慌症状的条件刺激并不局限于最初的条件刺激，而是被认为可以概括为与恐慌共同发生的刺激，从而导致恐慌线索的扩散。作者通过测试惊恐患者和健康受试者表现出条件性恐惧泛化的程度，对惊恐障碍的这种潜在相关性进行了基于实验室的评估。招募了19名DSM-IV-TR诊断为惊恐障碍的患者和19名健康对照受试者进行研究。恐惧泛化范式由10个大小不同的环组成，呈现在计算机显示器上;一个极端的大小是条件危险提示，另一个极端是条件安全提示，八个中间大小的环创造了一个从一个极端到另一个极端的连续相似性。通过肌电图（EMG）测量的条件性恐惧增强惊吓眨眼反射来评估泛化。惊恐肌电图显示，惊恐患者比对照组表现出更强的条件概括能力。恐慌患者的条件性恐惧一般化的环与三个单位的不同条件的危险线索，而概括在比较科目仅限于环与一个单位的不同。研究结果表明，恐慌症的恐惧过度概括的显着倾向，并提供了一种方法，以实验室为基础的调查，这个中央，但研究不足，条件反射相关的恐慌。鉴于恐惧条件反射的假定分子基础，这些结果可能对恐慌症的新治疗和预防具有启示。
Classical conditioning features prominently in many etiological accounts of panic disorder. According to such accounts, neutral conditioned stimuli present during panic attacks acquire panicogenic properties. Conditioned stimuli triggering panic symptoms are not limited to the original conditioned stimuli but are thought to generalize to stimuli resembling those co-occurring with panic, resulting in the proliferation of panic cues. The authors conducted a laboratory-based assessment of this potential correlate of panic disorder by testing the degree to which panic patients and healthy subjects manifest generalization of conditioned fear. Nineteen patients with a DSM-IV-TR diagnosis of panic disorder and 19 healthy comparison subjects were recruited for the study. The fear-generalization paradigm consisted of 10 rings of graded size presented on a computer monitor; one extreme size was a conditioned danger cue, the other extreme a conditioned safety cue, and the eight rings of intermediary size created a continuum of similarity from one extreme to the other. Generalization was assessed by conditioned fear potentiating of the startle blink reflex as measured with electromyography (EMG). Panic patients displayed stronger conditioned generalization than comparison subjects, as reflected by startle EMG. Conditioned fear in panic patients generalized to rings with up to three units of dissimilarity to the conditioned danger cue, whereas generalization in comparison subjects was restricted to rings with only one unit of dissimilarity. The findings demonstrate a marked proclivity toward fear overgeneralization in panic disorder and provide a methodology for laboratory-based investigations of this central, yet understudied, conditioning correlate of panic. Given the putative molecular basis of fear conditioning, these results may have implications for novel treatments and prevention in panic disorder.
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影响因子：
4.1
作者：
Lissek S;Rabin SJ;McDowell DJ;Dvir S;Bradford DE;Geraci M;Pine DS;Grillon C
通讯作者：
Grillon C
影响因子：
2.7
作者：
Land, C;Riccio, DC
通讯作者：
Riccio, DC
影响因子：
17.7
作者：
Shear, MK;Brown, TA;Papp, LA
通讯作者：
Papp, LA
DOI：
10.1037//0097-7403.4.2.95
发表时间：
1978-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
DAVIS, M;ASTRACHAN, DI
通讯作者：
ASTRACHAN, DI
影响因子：
4.1
作者：
WOLPE, J;ROWAN, VC
通讯作者：
ROWAN, VC