Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation.
Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation.
复制标题
应用烟酰胺（烟酰胺）控制皮肤衰老和色素沉着的机制基础和临床证据。
DOI：
10.3390/antiox10081315
复制
发表时间：
2021-08-21
期刊：
影响因子：
--
通讯作者：
Boo YC
中科院分区：
文献类型：
--
作者：
Boo YC
缺乏维生素B3（烟酸、烟酸）会导致系统性疾病糙皮病，根据其严重程度和持续时间，会导致皮炎、腹泻、痴呆，甚至可能死亡。维生素B3用于合成NAD+辅酶家族，有助于细胞能量代谢和防御系统。虽然烟酰胺（烟酰胺）主要用作维生素B3的营养补充剂，但其在制药和药妆方面的用途已被广泛探索。本文从烟酰胺的代谢途径出发，对其生物活性和药妆特性进行了综述。补充烟酰胺可恢复细胞NAD+池和线粒体能量，减轻氧化应激和炎症反应，增强细胞外基质和皮肤屏障，抑制皮肤色素沉着过程。在临床试验中，局部治疗烟酰胺，单独或与其他活性成分联合，可减少皮肤老化和色素沉着的进展。局部应用烟酰胺对皮肤耐受性良好。目前，没有令人信服的证据表明烟酰胺具有控制皮肤老化和色素沉着的特定分子靶点。这种物质被认为通过调节细胞的氧化还原状态以及由此产生的各种代谢物来维持皮肤稳态。因此，我们建议烟酰胺作为一种药妆成分可用于减缓皮肤老化和色素沉着，特别是对于老年人或由于内外部压力导致皮肤中NAD+池减少的患者。
Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and duration. Vitamin B3 is used in the synthesis of the NAD+ family of coenzymes, contributing to cellular energy metabolism and defense systems. Although nicotinamide (niacinamide) is primarily used as a nutritional supplement for vitamin B3, its pharmaceutical and cosmeceutical uses have been extensively explored. In this review, we discuss the biological activities and cosmeceutical properties of nicotinamide in consideration of its metabolic pathways. Supplementation of nicotinamide restores cellular NAD+ pool and mitochondrial energetics, attenuates oxidative stress and inflammatory response, enhances extracellular matrix and skin barrier, and inhibits the pigmentation process in the skin. Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials. Topically applied nicotinamide is well tolerated by the skin. Currently, there is no convincing evidence that nicotinamide has specific molecular targets for controlling skin aging and pigmentation. This substance is presumed to contribute to maintaining skin homeostasis by regulating the redox status of cells along with various metabolites produced from it. Thus, it is suggested that nicotinamide will be useful as a cosmeceutical ingredient to attenuate skin aging and hyperpigmentation, especially in the elderly or patients with reduced NAD+ pool in the skin due to internal or external stressors.
登录
查看更多内容
影响因子：
7.8
作者：
Borradaile, Nica M.;Pickering, J. Geoffrey
通讯作者：
Pickering, J. Geoffrey
DOI：
10.3390/antiox9090812
发表时间：
2020-09-01
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Boo YC
通讯作者：
Boo YC
影响因子：
2.3
作者：
Berardesca, E.;Ardigo, M.;Matts, P. J.
通讯作者：
Matts, P. J.
影响因子：
4.8
作者：
Aarhus, R;Graeff, RM;Lee, HC
通讯作者：
Lee, HC
影响因子：
64.8
作者：
Anderson, RM;Bitterman, KJ;Sinclair, DA
通讯作者：
Sinclair, DA