Clinical Significance of Procalcitonin, C-Reactive Protein, and Interleukin-6 in Helping Guide the Antibiotic Use for Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease.
Clinical Significance of Procalcitonin, C-Reactive Protein, and Interleukin-6 in Helping Guide the Antibiotic Use for Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease.
复制标题
降钙素原、C 反应蛋白和白细胞介素 6 在帮助指导慢性阻塞性肺疾病急性加重患者使用抗生素方面的临床意义。
DOI：
10.1155/2021/8879401
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ma X
中科院分区：
文献类型：
--
作者：
Song W;Wang Y;Tian F;Ge L;Shang X;Zeng Q;Feng N;Fan J;Wang J;Ma X
目前，抗生素在慢性阻塞性肺疾病急性加重期（AECOPD）患者中的使用标准存在争议。 本研究的目的是分析降钙素原（PCT）、C反应蛋白（CRP）和白细胞介素-6（IL-6）水平对指导AECOPD患者抗生素治疗的价值。 共有371例COPD或AECOPD患者入选本研究。在入院时获得临床和实验室数据，325例AECOPD患者和46例sCOPD患者接受抗生素治疗。采用受试者工作曲线（ROC）评价CRP、PCT和IL-6之间的关系。 本研究包括病历/病例对照1，COPD组（n = 46）和AECOPD组（n = 325），以及病历对照2，未更换抗生素组（n = 203）和更换抗生素组（n = 61）。病例1中AECOPD组CRP、PCT、IL-6水平均高于对照组（P < 0.05），ROC曲线显示IL-6的AUC值（0.773）和敏感性（71.7%）高于其他指标。PCT的特异性（93.5%）高于其他指标。病例2的ROC曲线结果显示，IL-6的AUC值（0.771）略高于PCT和CRP。CRP的敏感性（85.2%）和特异性（65.5%）高于其他指标。 AECOPD患者中IL-6和PCT升高，导致对AECOPD的诊断价值更高。CRP对AECOPD患者抗生素使用有较高的诊断价值。
Currently, standards of antibiotic use in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients are controversial. The aim of the present study was to analyze the value of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) levels to guide the antibiotic treatment of AECOPD patients. A total of 371 patients with COPD or AECOPD were included in the study. Clinical and laboratory data were obtained at admission, 325 AECOPD patients and 46 sCOPD patients treated with antibiotics. The receiver operating curve (ROC) was used to evaluate the relationship between CRP, PCT, and IL-6. This study included medical record/case control 1, the COPD group (n = 46) and the AECOPD group (n = 325), and medical record control 2, the nonchanged antibiotic group (n = 203) and the changed antibiotic group (n = 61). In case 1, CRP, PCT, and IL-6 levels in the AECOPD group were higher than that in the control group (P < 0.05), while the result of ROC showed that IL-6 had higher AUC values (0.773) and higher sensitivity (71.7%) than other indicators. The specificity of PCT (93.5%) is higher than other indicators. In case 2, ROC curve results showed that the AUC value of IL-6 (0.771) was slightly higher than PCT and CRP. The sensitivity (85.2%) and specificity (65.5%) of CRP were higher than other indicators. IL-6 and PCT were elevated in AECOPD patients, resulting in a higher diagnostic value for AECOPD. CRP had a higher diagnostic value for antibiotic use in AECOPD patients.
登录
查看更多内容
DOI：
10.1056/nejmoa1802670
发表时间：
2018-07-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Huang DT;Yealy DM;Filbin MR;Brown AM;Chang CH;Doi Y;Donnino MW;Fine J;Fine MJ;Fischer MA;Holst JM;Hou PC;Kellum JA;Khan F;Kurz MC;Lotfipour S;LoVecchio F;Peck-Palmer OM;Pike F;Prunty H;Sherwin RL;Southerland L;Terndrup T;Weissfeld LA;Yabes J;Angus DC;ProACT Investigators
通讯作者：
ProACT Investigators
影响因子：
4.3
作者：
Llor, Carl;Bjerrum, Lars;Caballero, Lidia
通讯作者：
Caballero, Lidia
影响因子：
3.5
作者：
Farahi N;Paige E;Balla J;Prudence E;Ferreira RC;Southwood M;Appleby SL;Bakke P;Gulsvik A;Litonjua AA;Sparrow D;Silverman EK;Cho MH;Danesh J;Paul DS;Freitag DF;Chilvers ER
通讯作者：
Chilvers ER
影响因子：
--
作者：
Shahriary A;Ghanei M;Rahmani H
通讯作者：
Rahmani H
影响因子：
1.6
作者：
Wang, Jinrong;Shang, Huimian;Cui, Zhaobo
通讯作者：
Cui, Zhaobo