Examination of the role of the cerebral cortex in the perception of pain using functional magnetic resonance imaging

Examination of the role of the cerebral cortex in the perception of pain using functional magnetic resonance imaging
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使用功能磁共振成像检查大脑皮层在疼痛感知中的作用

DOI:
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发表时间:
1999
影响因子:
3.7
通讯作者:
Y. Baron
Y. Baron
中科院分区:
医学3区
文献类型:
--
作者:
E. Disbrow;R. Baron;Y. Baron

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在下面的综述中,我们概述了与设计和解释疼痛感知功能成像研究相关的一些独特困难。与其他感觉方式不同,皮层对疼痛的处理是独特的,疼痛体验本身也是如此。与其他感觉系统不同,疼痛处理并不发生在皮层的一个专门区域。相反,伤害感受细胞稀疏地分布在躯体感觉皮层。此外,疼痛是独特的,因为它既有感觉辨别成分,也有情感动机成分,这可能是由不同的神经解剖学基础所决定的。最后,异常疼痛感觉,如神经性疼痛综合征,可能有不同的或额外的机制,需要特别考虑。我们已经用我们自己在急性疼痛和继发性机械性痛觉过敏方面的工作以及其他实验室的工作中的例子说明了这些观点。
In the following review we outline several of the unique difficulties associated with designing and interpreting functional imaging studies of pain perception. Unlike other sensory modalities, the cortical processing of pain is unique, as is the pain experience itself. Unlike other sensory systems, pain processing does not take place in one dedicated region of the cortex. Rather, nociceptive cells are sparsely distributed through the somatosensory cortex. Further, pain is singular in that it has both sensorydiscriminative and affective-motivational components, which are probably subserved by different neuroanatomic substrates. Finally, abnormal pain sensation, such as neuropathic pain syndromes, may have different or additional mechanisms that require special consideration. We have illustrated these points with examples from our own work on acute pain and secondary mechanical hyperalgesia, and work from other laboratories.
前顶叶皮质对应用于同一皮肤部位的触觉和皮肤加热刺激的反应。
DOI: 10.1152/jn.1996.75.6.2662
发表时间: 1996
期刊: Journal of neurophysiology.
影响因子: --
作者:
Tommerdahl,M;Delemos,KA;VierckJr,CJ;Favorov,OV;Whitsel,BL
通讯作者: Whitsel,BL
DOI: 10.1152/jn.1980.43.6.1594
发表时间: 1980-01-01
影响因子: 2.5
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DOI: 10.1113/jphysiol.1992.sp019068
发表时间: 1992-03-01
影响因子: 5.5
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