MicroRNAs in Age-Related Proteostasis and Stress Responses.
MicroRNAs in Age-Related Proteostasis and Stress Responses.
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DOI：
10.3390/ncrna9020026
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发表时间：
2023-04-13
期刊：
影响因子：
4.3
通讯作者：
Slack FJ
中科院分区：
文献类型：
--
作者：
Matai L;Slack FJ
衰老与通过蛋白质稳态（蛋白质稳态）机制下降而导致的受损和错误折叠蛋白质的积累有关，从而导致各种与年龄相关的蛋白质错误折叠疾病，例如亨廷顿氏病或帕金森氏病。细胞应激反应途径的效率也随着年龄的增长而减弱，进一步导致蛋白质稳态的维持失败。microRNA（miRNAs或miRs）是一类小的非编码RNA（ncRNA），其在3′UTR结合靶信使RNA，导致基因表达的转录后抑制。lin-4在C.在线虫中，许多miRNA在控制衰老过程中的作用已经在不同的生物体中被发现。最近的研究还表明，miRNA调节蛋白质稳态机制的不同组分以及对蛋白毒性应激的细胞反应途径，其中一些在衰老或与年龄相关的病理学中非常重要。在这里，我们对这些发现进行了综述，强调了单个miRNA在不同生物体中与年龄相关的蛋白质折叠和降解中的作用。我们还广泛总结了衰老过程中和各种年龄相关疾病中miRNAs与细胞器特异性应激反应途径之间的关系。
Aging is associated with the accumulation of damaged and misfolded proteins through a decline in the protein homeostasis (proteostasis) machinery, leading to various age-associated protein misfolding diseases such as Huntington’s or Parkinson’s. The efficiency of cellular stress response pathways also weakens with age, further contributing to the failure to maintain proteostasis. MicroRNAs (miRNAs or miRs) are a class of small, non-coding RNAs (ncRNAs) that bind target messenger RNAs at their 3′UTR, resulting in the post-transcriptional repression of gene expression. From the discovery of aging roles for lin-4 in C. elegans, the role of numerous miRNAs in controlling the aging process has been uncovered in different organisms. Recent studies have also shown that miRNAs regulate different components of proteostasis machinery as well as cellular response pathways to proteotoxic stress, some of which are very important during aging or in age-related pathologies. Here, we present a review of these findings, highlighting the role of individual miRNAs in age-associated protein folding and degradation across different organisms. We also broadly summarize the relationships between miRNAs and organelle-specific stress response pathways during aging and in various age-associated diseases.
影响因子：
2.7
作者：
Lin H;Zhang W;Zhou T;Li W;Chen Z;Ji C;Zhang C;He F
通讯作者：
He F
影响因子：
4.5
作者：
Brown KC;Montgomery TA
通讯作者：
Montgomery TA