Free swelling and confined smart hydrogels for applications in chemomechanical sensors for physiological monitoring.
Free swelling and confined smart hydrogels for applications in chemomechanical sensors for physiological monitoring.
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DOI：
10.1016/j.snb.2008.11.001
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发表时间：
2009-02-02
影响因子：
8.4
通讯作者：
Solzbacher, F.
中科院分区：
文献类型：
--
作者：
Lin, G.;Chang, S.;Kuo, C. -H.;Magda, J.;Solzbacher, F.
我们研究了用于将微型压力传感器转换为新型化学机械传感器的“智能”聚合物水凝胶薄膜。在这种通用的传感方法中，智能水凝胶被限制在多孔膜和压阻式压力传感器的隔膜之间。通过测量由水凝胶施加在压力传感器隔膜上的压力变化来检测通过膜的孔感测的环境分析物浓度的增加。我们比较这样的传感器的响应与响应的自由溶胀水凝胶相同的传感器内使用的。观察到传感器和游离水凝胶具有相当的平均响应时间。然而，与游离水凝胶不同，传感器的时间依赖性响应曲线在溶胀和去溶胀之间是高度不对称的，具有较小的去溶胀时间常数。我们还研究了增加传感器灵敏度的新方法，例如使用具有纳米多孔聚合物内层的双层膜，以及在压力下预加载水凝胶。在离子强度响应测试中，内膜的使用增加了传感器的灵敏度，而不增加平均响应时间，这是一种随膜含水率而变化的效果。
We investigate thin films of “smart” polymer hydrogels used to convert miniature pressure sensors into novel chemomechanical sensors. In this versatile sensing approach, a smart hydrogel is confined between a porous membrane and the diaphragm of a piezoresistive pressure transducer. An increase in the environmental analyte concentration, as sensed through the pores of the membrane, is detected by measuring the change in pressure exerted by the hydrogel on the pressure transducer diaphragm. We compare the response of such a sensor with the response of a free-swelling hydrogel identical to the one used within the sensor. The sensor and the free hydrogel are observed to have comparable mean response times. However, the time-dependent response curve of the sensor, unlike that of the free hydrogel, is highly asymmetric between swelling and deswelling, with a smaller time constant for deswelling. We also investigate novel methods for increasing sensor sensitivity, such as use of a two-layer membrane with a nanoporous polymer inner layer, and pre-loading of the hydrogel under pressure. In ionic strength response tests, use of an inner membrane increases sensor sensitivity without increasing mean response time, an effect that varies with membrane water fraction.
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