Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis.
Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis.
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DOI：
10.1371/journal.pone.0112108
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Babu S
中科院分区：
文献类型：
--
作者：
Kumar NP;Banurekha VV;Nair D;Sridhar R;Kornfeld H;Nutman TB;Babu S
细胞因子在肺结核合并2型糖尿病的发病机制中起重要作用。然而，PTB与糖尿病前期(Pdm)的细胞因子相互作用尚不清楚。为了确定符合的pdm对肺结核患者细胞因子水平的影响，我们检测了患有tb-pdm的个体血浆中一组细胞因子的循环水平，并将其与没有pdm的个体(tb-ndm)进行了比较。TB-PDM的特点是循环中1型(干扰素γ、肿瘤坏死因子α和IL-2)、17型(IL-17A和IL-17F)和其他促炎细胞因子(IL-1β、干扰素β和GM-CSF)水平升高。TB-PDM的特征还包括全身2型(IL-5)和调节性(IL-10和转化生长因子β)细胞因子水平的增加。此外，TB抗原刺激的全血也表现出促炎细胞因子(干扰素γ、肿瘤坏死因子α和IL-1β)水平的增加。然而，细胞因子与HbA1C水平或细菌负荷没有显示出任何显著的相关性。我们的数据显示，肺结核患者的糖尿病前期以细胞因子反应性升高为特征，这表明平衡的促炎和抗炎细胞因子环境是糖尿病前期与结核病共同发病的特征。
Cytokines play an important role in the pathogenesis of pulmonary tuberculosis (PTB) - Type 2 diabetes mellitus co-morbidity. However, the cytokine interactions that characterize PTB coincident with pre-diabetes (PDM) are not known. To identify the influence of coincident PDM on cytokine levels in PTB, we examined circulating levels of a panel of cytokines in the plasma of individuals with TB-PDM and compared them with those without PDM (TB-NDM). TB-PDM is characterized by elevated circulating levels of Type 1 (IFNγ, TNFα and IL-2), Type 17 (IL-17A and IL-17F) and other pro-inflammatory (IL-1β, IFNβ and GM-CSF) cytokines. TB-PDM is also characterized by increased systemic levels of Type 2 (IL-5) and regulatory (IL-10 and TGFβ) cytokines. Moreover, TB antigen stimulated whole blood also showed increased levels of pro-inflammatory (IFNγ, TNFα and IL-1β) cytokines as well. However, the cytokines did not exhibit any significant correlation with HbA1C levels or with bacterial burdens. Our data reveal that pre-diabetes in PTB individuals is characterized by heightened cytokine responsiveness, indicating that a balanced pro and anti - inflammatory cytokine milieu is a feature of pre-diabetes - TB co-morbidity.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.5
作者：
Forouhi, N. G.;Luan, J.;Wareham, N. J.
通讯作者：
Wareham, N. J.
影响因子：
11.8
作者：
Restrepo, Blanca I.;Fisher-Hoch, Susan P.;McCormick, Joseph B.
通讯作者：
McCormick, Joseph B.
DOI：
10.1016/s0140-6736(12)60283-9
发表时间：
2012-06-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Tabák AG;Herder C;Rathmann W;Brunner EJ;Kivimäki M
通讯作者：
Kivimäki M
影响因子：
56.3
作者：
Dooley, Kelly E.;Chaisson, Richard E.
通讯作者：
Chaisson, Richard E.