Pressor Hormones in Elderly Hypertensive Persons
Pressor Hormones in Elderly Hypertensive Persons
复制标题
老年高血压患者的升压激素
DOI：
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
H. Gavras
中科院分区：
文献类型：
--
作者：
M. Bursztyn;M. Bresnahan;I. Gavras;H. Gavras
The purpose of this study was to examine pressor hormones and platelet o^-adrenergic receptors in elderly unmedicated free-living subjects. Eighty-seven subjects, 70±5 years old (mean±SD), hypertensive or nonnotensive (blood pressure < 160/90 mm Hg) were recruited for measurement of blood levels of norepinephrine, epinephrine, and vasopressin, as well as density and affinity of «2-adrenergic receptors from platelet membranes, assessed by maximal binding (B^J and dissociation constant (A^) of rauwolscine. They were separated into white hypertensive (n=22) or normotensive (n=41), and black hypertensive (n=ll) or nonnotensive (n=13) groups, with similar age distribution throughout and similar blood pressure levels in the hypertensive and normotensive groups. Vasopressin was higher in the black hypertensive than white hypertensive group (1.5±1.0 vs. 0.7±0.5 pg/ml, respectively, p<0.005), whereas epinephrine correlated inversely with diastolic blood pressure (r= -0.7,p<0.02, in the black hypertensive group). K^ was higher in the black normotensive group than in the other groups (1.6±0.6 vs. 1.0±0.2,1.1 ±0.3, or 1.0 ±0.3 nM in the white normotensive, black hypertensive, or white hypertensive group, respectively, /?< 0.002). B^ was no different among groups but was significantly correlated with vasopressin levels for the whole group (r=0.4,/?<0.0004) although no such correlation existed within the black hypertensive group. The data suggest that various vasoconstrictor systems participate to different extents in the mechanisms generating and sustaining hypertension in elderly white and black subjects. (Hypertension 1990;15(suppl I):I-88-I-92)
高盐摄入和低盐摄入大鼠高血压发展过程中的中枢α-肾上腺素受体。
影响因子：
4.9
作者：
Bresnahan,MR;Gavras,I;Hatinoglou,S;Muller,RE;Gavras,H
通讯作者：
Gavras,H
老年人血小板α2-肾上腺素能受体-腺苷酸环化酶复合物的功能解偶联。
DOI：
10.1210/jcem-64-6-1160
发表时间：
1987
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Supiano,MA;Linares,OA;Halter,JB;Reno,KM;Rosen,SG
通讯作者：
Rosen,SG