Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases.
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases.
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DOI：
10.1002/med.21743
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发表时间：
2021-01
影响因子：
13.3
通讯作者：
Wagner H
中科院分区：
文献类型：
--
作者：
Panossian AG;Efferth T;Shikov AN;Pozharitskaya ON;Kuchta K;Mukherjee PK;Banerjee S;Heinrich M;Wu W;Guo DA;Wagner H
适应原包括一类草药和营养产品，可促进生物体在压力下的适应性、恢复力和存活。本综述的目的是总结有关各种传统医疗系统（TMS）和传统医学中使用的常见适应性植物的知识，并为它们在治疗应激诱导和衰老相关疾病中的应用提供现代理论基础。适应原对神经内分泌免疫系统具有多效性作用，这解释了它们用于治疗各种疾病的传统用途。它们表现出双相剂量效应反应：在低剂量下，它们作为轻度应激模拟物发挥作用，激活适应性应激反应信号通路以科普严重应激。这与它们用于预防过早衰老和保持良好健康和活力的传统用途一致。然而，适应原的潜力仍然很少探索。压力和衰老相关疾病的治疗需要新的方法。适应性植物的一些组合由于它们在生物体中的协同相互作用而提供了独特的效果，这是任何成分都无法独立获得的。这一领域的进一步进展需要集中在发现基于传统医学概念的适应原的新组合上。包括网络药理学和系统药理学在内的强大而严格的方法可以帮助分析潜在的协同效应，以及更广泛地分析适应原的未来用途。总之，适应性概念的演变导致了TMS的基础知识和对整体方法的新理解。它为它们在应激诱导和衰老相关疾病中的应用提供了理论基础。
Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern rationale for their use in the treatment of stress‐induced and aging‐related disorders. Adaptogens have pharmacologically pleiotropic effects on the neuroendocrine‐immune system, which explain their traditional use for the treatment of a wide range of conditions. They exhibit a biphasic dose‐effect response: at low doses they function as mild stress‐mimetics, which activate the adaptive stress‐response signaling pathways to cope with severe stress. That is in line with their traditional use for preventing premature aging and to maintain good health and vitality. However, the potential of adaptogens remains poorly explored. Treatment of stress and aging‐related diseases require novel approaches. Some combinations of adaptogenic plants provide unique effects due to their synergistic interactions in organisms not obtainable by any ingredient independently. Further progress in this field needs to focus on discovering new combinations of adaptogens based on traditional medical concepts. Robust and rigorous approaches including network pharmacology and systems pharmacology could help in analyzing potential synergistic effects and, more broadly, future uses of adaptogens. In conclusion, the evolution of the adaptogenic concept has led back to basics of TMS and a new level of understanding of holistic approach. It provides a rationale for their use in stress‐induced and aging‐related diseases.
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影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/j.ijdevneu.2011.02.006
发表时间：
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期刊：
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作者：
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影响因子：
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