Functions of Sphingolipids in Pathogenesis During Host-Pathogen Interactions.
Functions of Sphingolipids in Pathogenesis During Host-Pathogen Interactions.
复制标题
鞘脂在宿主与病原体相互作用过程中发病机制中的功能
DOI：
10.3389/fmicb.2021.701041
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发表时间：
2021
影响因子：
5.2
通讯作者：
Yao N
中科院分区：
文献类型：
--
作者：
Wang J;Chen YL;Li YK;Chen DK;He JF;Yao N
鞘脂是一类膜脂，在从酵母到动物的生物体中充当重要的结构和信号生物活性分子。最近的研究强调了鞘脂作为信号分子在微生物病原体（包括细菌、真菌和病毒）的发育和致病性中的重要性。特别是，鞘脂在微生物致病过程中调节微生物与宿主之间的微妙平衡中发挥关键作用。一些病原体，如细菌和病毒，利用宿主鞘脂促进发育和感染，而来自宿主和病原体的鞘脂参与真菌-宿主相互作用。此外，鞘脂的调节作用已被描述，但其对宿主生理和代谢的影响仍有待阐明。在这里，我们总结了目前的知识状态的作用，鞘脂的发病机制和与宿主因素的相互作用，包括鞘脂如何修改病原体和宿主代谢的重点是发病机制的调节剂和相关的代谢酶。此外，我们还讨论了靶向鞘脂的新观点，这些鞘脂在宿主-微生物相互作用中发挥作用，作为传染病的新治疗策略。
Sphingolipids are a class of membrane lipids that serve as vital structural and signaling bioactive molecules in organisms ranging from yeast to animals. Recent studies have emphasized the importance of sphingolipids as signaling molecules in the development and pathogenicity of microbial pathogens including bacteria, fungi, and viruses. In particular, sphingolipids play key roles in regulating the delicate balance between microbes and hosts during microbial pathogenesis. Some pathogens, such as bacteria and viruses, harness host sphingolipids to promote development and infection, whereas sphingolipids from both the host and pathogen are involved in fungus–host interactions. Moreover, a regulatory role for sphingolipids has been described, but their effects on host physiology and metabolism remain to be elucidated. Here, we summarize the current state of knowledge about the roles of sphingolipids in pathogenesis and interactions with host factors, including how sphingolipids modify pathogen and host metabolism with a focus on pathogenesis regulators and relevant metabolic enzymes. In addition, we discuss emerging perspectives on targeting sphingolipids that function in host–microbe interactions as new therapeutic strategies for infectious diseases.
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