Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases.
Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases.
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DOI：
10.4155/fmc.12.122
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发表时间：
2012-09
影响因子：
4.2
通讯作者：
Glicksman MA
中科院分区：
文献类型：
--
作者：
Lin CL;Kong Q;Cuny GD;Glicksman MA
Glutamate is the primary excitatory amino acid neurotransmitter in the CNS. The concentration of glutamate in the synaptic cleft is tightly controlled by interplay between glutamate release and glutamate clearance. Abnormal glutamate release and/or dysfunction of glutamate clearance can cause overstimulation of glutamate receptors and result in neuronal injury known as excitotoxicity. The glial glutamate transporter EAAT2 plays a major role in glutamate clearance. Dysfunction or reduced expression of EAAT2 has been documented in many neurodegenerative diseases. In addition, many studies in animal models of disease indicate that increased EAAT2 expression provides neuronal protection. Here, we summarize these studies and suggest that EAAT2 is a potential target for the prevention of excitotoxicity. EAAT2 can be upregulated by transcriptional or translational activation. We discuss current progress in the search for EAAT2 activators, which is a promising direction for the treatment of neurodegenerative diseases.
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影响因子：
4.1
作者：
Bullock, R;Zauner, A;Young, HF
通讯作者：
Young, HF
影响因子：
4.8
作者：
Butchbach, MER;Tian, GL;Lin, CLG
通讯作者：
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通讯作者：
DIEMER, NH
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作者：
Bjornsen, L. P.;Eid, T.;de Lanerolle, N. C.
通讯作者：
de Lanerolle, N. C.
影响因子：
3.4
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Bézard, E;Boraud, T;Gross, CE
通讯作者：
Gross, CE