The Role of Androgens and Androgen Receptor in Human Bladder Cancer.
The Role of Androgens and Androgen Receptor in Human Bladder Cancer.
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DOI：
10.3390/biom11040594
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发表时间：
2021-04-18
期刊：
影响因子：
5.5
通讯作者：
Escobar-Cabrera J
中科院分区：
文献类型：
--
作者：
Martínez-Rojo E;Berumen LC;García-Alcocer G;Escobar-Cabrera J
膀胱癌（尿路上皮癌）是最常诊断的肿瘤之一，全世界每年估计有50万新发病例和20万例死亡。这种疾病主要影响男性。男性患膀胱癌的风险比女性高（4：1）。吸烟和接触芳香胺和苯胺染料等化学物质已被确定为膀胱癌的危险因素，并可能导致性别差异。男性内生殖器，包括尿道和前列腺，来自尿道上皮窦内胚层;这两种组织表达雄激素受体（AR）。几项研究表明，AR在包括膀胱癌在内的不同类型癌症的发生和发展中起着重要作用。在这篇文章中，我们总结了现有的数据，有助于解释AR在膀胱癌的发展和进展中的作用，以及用于治疗的疗法。
Bladder cancer (urothelial carcinoma) is one of the most frequently diagnosed neoplasms, with an estimated half a million new cases and 200,000 deaths per year worldwide. This pathology mainly affects men. Men have a higher risk (4:1) of developing bladder cancer than women. Cigarette smoking and exposure to chemicals such as aromatic amines, and aniline dyes have been established as risk factors for bladder cancer and may contribute to the sex disparity. Male internal genitalia, including the urothelium and prostate, are derived from urothelial sinus endoderm; both tissues express the androgen receptor (AR). Several investigations have shown evidence that the AR plays an important role in the initiation and development of different types of cancer including bladder cancer. In this article, we summarize the available data that help to explain the role of the AR in the development and progression of bladder cancer, as well as the therapies used for its treatment.
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作者：
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