Acid-Sensing Ion Channel 1a Contributes to the Prefrontal Cortex Ischemia-Enhanced Neuronal Activities in the Amygdala.
Acid-Sensing Ion Channel 1a Contributes to the Prefrontal Cortex Ischemia-Enhanced Neuronal Activities in the Amygdala.
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DOI：
10.3390/brainsci13121684
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发表时间：
2023-12-07
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
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作者：
中风后，杏仁核相关疾病的出现构成了一个重大挑战，对中风后的心理健康产生了严重影响，包括焦虑和抑郁等症状。这些疾病不仅阻碍中风后的恢复，而且还增加死亡率。尽管影响深远，但中风后杏仁核功能异常的确切起源仍然难以捉摸。作为缺血时降低脑pH的靶点，酸敏感离子通道（ASIC）参与了缺血后的突触传递，暗示了它们在中风后重塑神经回路中的潜在作用。本研究深入探讨了中风后改变和ASIC之间的有趣关系，特别是专注于突触后ASIC 1a增强杏仁核后，前额叶皮层（PFC）缺血内皮素-1（ET-1）注射诱导。我们的研究结果有趣地说明，mPFC缺血不仅加重PFC的杏仁核电路，但也牵连ASIC 1a在促进缺血后增强突触可塑性。相反，ASIC 1a的缺乏削弱了缺血引起的杏仁核长时程增强（LTP）的诱导。这项关键的研究引入了一个新的概念，有可能开辟一个全新的研究途径，从而显着提高我们对中风后神经回路重构的复杂机制的理解。重要的是，这些发现有望为开创性的治疗干预铺平道路。
Following a stroke, the emergence of amygdala-related disorders poses a significant challenge, with severe implications for post-stroke mental health, including conditions such as anxiety and depression. These disorders not only hinder post-stroke recovery but also elevate mortality rates. Despite their profound impact, the precise origins of aberrant amygdala function after a stroke remain elusive. As a target of reduced brain pH in ischemia, acid-sensing ion channels (ASICs) have been implicated in synaptic transmission after ischemia, hinting at their potential role in reshaping neural circuits following a stroke. This study delves into the intriguing relationship between post-stroke alterations and ASICs, specifically focusing on postsynaptic ASIC1a enhancement in the amygdala following prefrontal cortex (PFC) ischemia induced by endothelin-1 (ET-1) injection. Our findings intriguingly illustrate that mPFC ischemia not only accentuates the PFC to the amygdala circuit but also implicates ASIC1a in fostering augmented synaptic plasticity after ischemia. In contrast, the absence of ASIC1a impairs the heightened induction of long-term potentiation (LTP) in the amygdala induced by ischemia. This pivotal research introduces a novel concept with the potential to inaugurate an entirely new avenue of inquiry, thereby significantly enhancing our comprehension of the intricate mechanisms underlying post-stroke neural circuit reconfiguration. Importantly, these revelations hold the promise of paving the way for groundbreaking therapeutic interventions.
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从杏仁核中的电路到行为。
影响因子：
64.8
作者：
Janak PH;Tye KM
通讯作者：
Tye KM
影响因子：
8.3
作者：
Cheng, Bastian;Forkert, Nils Daniel;Thomalla, Goetz
通讯作者：
Thomalla, Goetz
DOI：
10.1073/pnas.0308753101
发表时间：
2004-03-09
影响因子：
11.1
作者：
Wemmie, JA;Coryell, MW;Welsh, MJ
通讯作者：
Welsh, MJ
DOI：
10.1523/jneurosci.0360-09.2009
发表时间：
2009-04-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Coryell MW;Wunsch AM;Haenfler JM;Allen JE;Schnizler M;Ziemann AE;Cook MN;Dunning JP;Price MP;Rainier JD;Liu Z;Light AR;Langbehn DR;Wemmie JA
通讯作者：
Wemmie JA
影响因子：
6.2
作者：
REHNCRONA, S
通讯作者：
REHNCRONA, S