Brain viscoelasticity alteration in chronic-progressive multiple sclerosis.
Brain viscoelasticity alteration in chronic-progressive multiple sclerosis.
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DOI：
10.1371/journal.pone.0029888
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Wuerfel J
中科院分区：
文献类型：
--
作者：
Streitberger KJ;Sack I;Krefting D;Pfüller C;Braun J;Paul F;Wuerfel J
粘弹性性质以高灵敏度在多个尺度上指示生物组织中的结构改变。磁共振弹性成像（MRE）是一种直接可视化和定量测量体内生物力学组织特性的新技术。MRE最近发现，早期复发缓解型多发性硬化症（MS）与大脑机械完整性的整体下降有关。本研究解决MRE和MR容量测定在慢性进展性疾病的MS过程中。我们确定了粘弹性参数的脑实质中的23 MS患者的原发性或继发性慢性进展性疾病的过程中相比，38个年龄和性别匹配的健康人的多频MRE，并与临床数据，T2病变负荷和脑体积的结果。根据springpot模型推导出两个粘弹性参数，剪切弹性μ和幂律指数α，并与复发-缓解型MS的文献值进行比较。在慢性进展型MS患者中，与健康对照组相比，μ和α分别降低20.5%和6.1%。MR容量测定法产生了较弱的相关性：考虑到脑实质分数，MS患者的总脑容量损失在7.5%和1.7%的范围内。所有结果均具有显著性（P<0.001）。与早期复发缓解型疾病相比，慢性进展型MS疾病病程显示脑剪切弹性显著降低。幂律指数α仅在MS的慢性进展阶段降低，表明由于慢性神经炎症导致的脑机械网络几何结构的改变。
Viscoelastic properties indicate structural alterations in biological tissues at multiple scales with high sensitivity. Magnetic Resonance Elastography (MRE) is a novel technique that directly visualizes and quantitatively measures biomechanical tissue properties in vivo. MRE recently revealed that early relapsing-remitting multiple sclerosis (MS) is associated with a global decrease of the cerebral mechanical integrity. This study addresses MRE and MR volumetry in chronic-progressive disease courses of MS. We determined viscoelastic parameters of the brain parenchyma in 23 MS patients with primary or secondary chronic progressive disease course in comparison to 38 age- and gender-matched healthy individuals by multifrequency MRE, and correlated the results with clinical data, T2 lesion load and brain volume. Two viscoelastic parameters, the shear elasticity μ and the powerlaw exponent α, were deduced according to the springpot model and compared to literature values of relapsing-remitting MS. In chronic-progressive MS patients, μ and α were reduced by 20.5% and 6.1%, respectively, compared to healthy controls. MR volumetry yielded a weaker correlation: Total brain volume loss in MS patients was in the range of 7.5% and 1.7% considering the brain parenchymal fraction. All findings were significant (P<0.001). Chronic-progressive MS disease courses show a pronounced reduction of the cerebral shear elasticity compared to early relapsing-remitting disease. The powerlaw exponent α decreased only in the chronic-progressive stage of MS, suggesting an alteration in the geometry of the cerebral mechanical network due to chronic neuroinflammation.
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