Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model.
Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model.
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重组人粒细胞巨噬细胞集落刺激因子 (GM-CSF) 可缩短灵长类动物模型自体骨髓移植后中性粒细胞减少症的时间。
DOI：
10.1172/jci113106
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
G. Nathan
中科院分区：
文献类型：
--
作者：
A. Nienhuis;Robert E. Donahue;Stefan Karlsson;Steve C. Clark;B. Agricola;Natalie Antinoff;J. Pierce;Patricia Tumer;W. F. Anderson;David;G. Nathan
在灵长类动物模型上观察了粒细胞-巨噬细胞集落刺激因子（GM-CSF）对自体骨髓移植后造血重建的影响。在移植前和移植后或仅在移植程序后，对动物连续静脉输注重组人GM-CSF数天。骨髓消融通过全身照射完成。在两组动物中，中性粒细胞计数在移植后8-9天达到1，000/mm 3，而两个同期对照组的间隔时间为17和24天。停用GM-CSF后，中性粒细胞计数降至与未治疗对照组相当的值。在5只动物中的4只中也观察到血小板生成的加速恢复。另外两只动物最初在移植后几周给予GM-CSF，因为植入不足。观察到中性粒细胞和血小板计数迅速和持续增加。我们的结论是，GM-CSF可能是有用的，在加速骨髓重建。
The effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on hematopoietic reconstitution after autologous bone marrow transplantation was evaluated in a primate model. Animals were given a continuous intravenous infusion of recombinant human GM-CSF for several days both before and after transplantation or only after the transplant procedure. Marrow ablation was accomplished by total body irradiation. In both groups of animals, the neutrophil count reached 1,000/mm3 by 8-9 d posttransplant compared with an interval of 17 and 24 d for two concurrent controls. After withdrawal of GM-CSF, neutrophil counts fell to values comparable to those observed in untreated controls. Accelerated recovery of platelet production was also observed in four of the five animals. Two additional animals were initially given GM-CSF several weeks posttransplantation because of inadequate engraftment. Prompt and sustained increases in neutrophil and platelet counts were observed. We conclude that GM-CSF may be useful in accelerating bone marrow reconstitution.
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粒细胞-巨噬细胞集落刺激因子与正常和白血病人骨髓细胞的高亲和力结合。
DOI：
10.1073/pnas.83.3.669
发表时间：
1986
影响因子：
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影响因子：
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影响因子：
20.3
作者：
Begley,CG;Lopez,AF;Nicola,NA;Warren,DJ;Vadas,MA;Sanderson,CJ;Metcalf,D
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