Estradiol and progesterone differentially regulate the dendritic arbor of neurons in the hypothalamic ventromedial nucleus of the female rat (Rattus norvegicus).
Estradiol and progesterone differentially regulate the dendritic arbor of neurons in the hypothalamic ventromedial nucleus of the female rat (Rattus norvegicus).
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DOI：
10.1002/cne.21816
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发表时间：
2008-10-20
影响因子：
2.5
通讯作者：
Flanagan-Cato, Loretta M.
中科院分区：
文献类型：
--
作者：
Griffin, Gerald D.;Flanagan-Cato, Loretta M.
下丘脑腹内侧核（VMH）及其主要分支，背内侧和腹外侧VMH（分别为dmVMH和vlVMH），已被广泛研究其在女性性行为中的作用。这种行为由vlVMH通过雌二醇与孕酮结合的细胞作用控制。虽然单独用雌二醇治疗对vlVMH中神经元形态的影响已被研究，但关于雌二醇和孕酮对神经元结构的联合作用知之甚少。本研究采用高尔基体浸渍法研究雌二醇单独处理和雌二醇与孕酮联合处理对VMH神经元树突的影响。vlVMH与dmVMH中VMH神经元的树突乔木有些不同，在vlVMH中具有更长和更多的树突。单用雌二醇治疗引起vlVMH中长初级树突长度的显著减少，但在dmVMH中没有。雌二醇诱导的长初级树突在vlVMH的收缩逆转孕激素治疗4小时内。dmVMH和vlVMH的树突状动脉的差异进一步支持了这两个区域具有不同的神经连接模式的观点。此外，这项研究是第一个报告的相反的影响，雌二醇单独与雌二醇加孕酮对vlVMH神经元的树突状乔木。这些结果表明，雌二醇单独对交配行为产生适度影响的结构机制，同时为其充分表达奠定了基础。
The ventromedial nucleus of the hypothalamus (VMH), with its major subdivisions, the dorsomedial and ventrolateral VMH (dmVMH and vlVMH, respectively), has been studied extensively for its role in female sexual behavior. This behavior is controlled by the vlVMH through the cellular actions of estradiol combined with progesterone. Although the effects of treatment with estradiol alone on neuronal morphology in the vlVMH have been examined, much less is known about the combined effects of estradiol and progesterone on neuronal structure. The present study employed Golgi impregnation to investigate the effects of estradiol treatment alone vs. estradiol combined with progesterone treatment on dendritic arbor of VMH neurons. The dendritic arbor of VMH neurons was somewhat different in the vlVMH vs. the dmVMH, with longer and more dendrites in the vlVMH. Estradiol treatment alone caused a marked reduction in the length of long primary dendrites in the vlVMH, but not in the dmVMH. The estradiol-induced retraction of long primary dendrites in the vlVMH was reversed within 4 hours of progesterone treatment. The differences in the dendritic arbors of dmVMH and vlVMH provide further support for the notion that these two regions have different patterns of neural connectivity. In addition, this study is the first to report opposing effects of estradiol alone vs. estradiol plus progesterone on the dendritic arbor of neurons in the vlVMH. These results suggest a structural mechanism for estradiol alone to have a modest effect on mating behavior while setting the stage for its ample expression.
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影响因子：
5.3
作者：
Hübschle, T;Thom, E;Meyerhof, W
通讯作者：
Meyerhof, W
DOI：
10.3181/00379727-51-13979
发表时间：
1942-12-01
影响因子：
--
作者：
Beach, FA
通讯作者：
Beach, FA
影响因子：
4.8
作者：
Calizo, LH;Flanagan-Cato, LM
通讯作者：
Flanagan-Cato, LM
影响因子：
4.1
作者：
DEKLOET, ER;VOORHUIS, DAM;ELANDS, J
通讯作者：
ELANDS, J
影响因子：
4.8
作者：
Flanagan-Cato, Loretta M.;Fluharty, Steven J.;LaBelle, Denise R.
通讯作者：
LaBelle, Denise R.