Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer.
Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer.
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8q24长链非编码RNA PRNCR1多态性与结直肠癌风险的关联
DOI：
10.1186/1756-9966-32-104
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发表时间：
2013-12-13
期刊：
影响因子：
--
通讯作者：
Gao L
中科院分区：
文献类型：
--
作者：
Li L;Sun R;Liang Y;Pan X;Li Z;Bai P;Zeng X;Zhang D;Zhang L;Gao L
全基因组关联研究已经确定8q24的遗传变异与结直肠癌（CRC）的易感性有关。最近，一个位于8q24的新型lncRNA （PRNCR1）被发现。lncRNAs中的单核苷酸多态性（snp）可能影响mRNA的剪接过程和构象的稳定性，从而导致其相互作用伙伴的修饰。我们假设lncRNA PRNCR1的snp可能与结直肠癌的风险有关。我们进行了一项病例对照研究，使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对908名受试者（包括313例CRC患者和595名对照组）的lncRNA PRNCR1的5个标签snp进行了基因分型。在整体分析中，我们发现rs13252298和rs1456315与CRC风险显著降低相关。在分层分析中，我们发现携带rs1456315G的结直肠癌患者可能肿瘤大小大于5 cm （G vs. a：调整OR = 1.56, 95% CI: 1.10-2.23）。此外，携带rs7007694C和rs16901946G基因的患者发生低分化CRC的风险降低，而携带rs1456315G基因的患者发生低分化CRC的风险增加。这些发现表明，lncRNA PRNCR1中的snp可能与结直肠癌的易感性有关。
Genome-wide association studies have identified that genetic variants in 8q24 confer susceptibility to colorectal cancer (CRC). Recently, a novel lncRNA (PRNCR1) that located in the 8q24 was discovered. Single nucleotide polymorphisms (SNPs) in the lncRNAs may influence the process of splicing and stability of mRNA conformation, resulting in the modification of its interacting partners. We hypothesized that SNPs in the lncRNA PRNCR1 may be related to the risk of CRC. We conducted a case–control study and genotyped five tag SNPs in the lncRNA PRNCR1 in 908 subjects including 313 cases with CRC and 595 control subjects using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) assay. In overall analyses, we found that the rs13252298 and rs1456315 were associated with significantly decreased risks of CRC. In stratification analyses, we found that CRC patients carrying the rs1456315G were likely to have a tumor size of greater than 5 cm (G vs. A: adjusted OR = 1.56, 95% CI: 1.10-2.23). Additionally, patients with the rs7007694C and rs16901946G had decreased risks to develop poorly differentiated CRC, whereas patients with the rs1456315G had an increased risk to develop poorly differentiated CRC. These findings suggest that SNPs in the lncRNA PRNCR1 may contribute to susceptibility to CRC.
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影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
影响因子：
4.5
作者：
Burd CE;Jeck WR;Liu Y;Sanoff HK;Wang Z;Sharpless NE
通讯作者：
Sharpless NE
影响因子：
64.8
作者：
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影响因子：
11.2
作者：
Barsyte-Lovejoy, Dalia;Lau, Suzanne K.;Penn, Linda Z.
通讯作者：
Penn, Linda Z.
影响因子：
8
作者：
Lin, R.;Maeda, S.;Edgington, T. S.
通讯作者：
Edgington, T. S.