Sex differences and autism: brain function during verbal fluency and mental rotation.
Sex differences and autism: brain function during verbal fluency and mental rotation.
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DOI：
10.1371/journal.pone.0038355
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Critchley HD
中科院分区：
文献类型：
--
作者：
Beacher FD;Radulescu E;Minati L;Baron-Cohen S;Lombardo MV;Lai MC;Walker A;Howard D;Gray MA;Harrison NA;Critchley HD
自闭症谱系条件（ASC）影响男性多于女性。这表明自闭症的神经生物学：1)可能与典型的性别分化机制重叠，或2)在自闭症如何在男性和女性中表达时交替反映性别特异性。在这里，我们使用功能磁共振成像（fMRI）来验证这些替代假设。15名患有阿斯伯格综合症（AS）的男性和14名女性，以及16名典型发展中的男性和16名典型发展中的女性在进行心理旋转和语言流畅性任务时接受了功能磁共振成像检查。所有小组都同样出色地完成了任务。在语言流畅性任务中，尽管任务表现相同，但与对照组相比，男性和女性AS患者的左枕顶叶和下前额叶活动都表现出增强的激活。在心理旋转过程中，在枕叶、颞叶、顶叶和额叶中部区域存在显著的性别诊断相互作用，与AS女性和典型男性相比，AS男性和典型女性的激活程度更高。这些发现表明，自闭症和性之间存在着复杂的关系，这种关系在语言和视觉空间领域中表现得不同。
Autism spectrum conditions (ASC) affect more males than females. This suggests that the neurobiology of autism: 1) may overlap with mechanisms underlying typical sex-differentiation or 2) alternately reflect sex-specificity in how autism is expressed in males and females. Here we used functional magnetic resonance imaging (fMRI) to test these alternate hypotheses. Fifteen men and fourteen women with Asperger syndrome (AS), and sixteen typically developing men and sixteen typically developing women underwent fMRI during performance of mental rotation and verbal fluency tasks. All groups performed the tasks equally well. On the verbal fluency task, despite equivalent task-performance, both males and females with AS showed enhanced activation of left occipitoparietal and inferior prefrontal activity compared to controls. During mental rotation, there was a significant diagnosis-by-sex interaction across occipital, temporal, parietal, middle frontal regions, with greater activation in AS males and typical females compared to AS females and typical males. These findings suggest a complex relationship between autism and sex that is differentially expressed in verbal and visuospatial domains.
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DOI：
10.1098/rstb.2002.1206
发表时间：
2003-02-28
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Baron-Cohen, S;Richler, J;Wheelwright, S
通讯作者：
Wheelwright, S
影响因子：
3.6
作者：
Gauthier, Christophe T.;Duyme, Michel;Capron, Christiane
通讯作者：
Capron, Christiane
影响因子：
2.5
作者：
Clements-Stephens AM;Rimrodt SL;Cutting LE
通讯作者：
Cutting LE
影响因子：
9.8
作者：
Baron-Cohen S;Lombardo MV;Auyeung B;Ashwin E;Chakrabarti B;Knickmeyer R
通讯作者：
Knickmeyer R
影响因子：
10.5
作者：
Bejerot, Susanne;Eriksson, Jonna M.;Eriksson, Elias
通讯作者：
Eriksson, Elias