A Combined Long Noncoding RNA Signature as a Candidate Prognostic Biomarker for Ovarian Cancer.
A Combined Long Noncoding RNA Signature as a Candidate Prognostic Biomarker for Ovarian Cancer.
复制标题
DOI：
10.3389/fonc.2021.624240
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Yang G
中科院分区：
文献类型：
--
作者：
Li H;Wang S;Yao Q;Liu Y;Yang J;Xu L;Yang G
Dysregulated long noncoding RNAs (lncRNAs) contributing to ovarian cancer (OC) development may serve as prognostic biomarker. We aimed to explore a lncRNA signature to serve as prognostic biomarker of OC. Univariate Cox regression was conducted on the lncRNA expression dataset from the TCGA cohort, and 246 genes significantly associated with survival were retained for building a model. A random forest survival model was carried out, and a model was developed using 6 genes with the highest frequency. The selected genes were applied in a Cox multivariate regression model for prognostic prediction by calculating the risk score. We also used CCK-8, EdU, and colony formation assays to validate the function of these lncRNAs in OC cells. This study confirmed that the 6-lncRNA combined signature was related to OC prognosis. Systematic analysis demonstrated that lncRNA-associated genes were enriched in oncogenic signalling pathways. Five out of the 6 lncRNAs participated in OC proliferation. We established a 6-lncRNA combined signature for OC prognosis, which may serve as powerful prognostic biomarker for OC after further validation.
登录
查看更多内容
影响因子：
4
作者：
Behera, Abhijeet;Ashraf, Rahail;Kumar, Sanjay
通讯作者：
Kumar, Sanjay
影响因子：
4.8
作者：
Hahn, Nina;Bueschgens, Luca;Heinrich, Ralf
通讯作者：
Heinrich, Ralf
DOI：
10.1097/gme.0000000000001655
发表时间：
2020-11-01
期刊：
MENOPAUSE-THE JOURNAL OF THE MENOPAUSE SOCIETY
影响因子：
--
作者：
Si, Lihui;Chen, Jun;Jia, Yan
通讯作者：
Jia, Yan
影响因子：
4
作者：
Pan Y;Jia LP;Liu Y;Han Y;Li Q;Zou Q;Zhang Z;Huang J;Deng Q
通讯作者：
Deng Q
结核病患者外周血中潜在生物标志物及相关转录因子的鉴定
DOI：
10.3390/ijerph17196993
发表时间：
2020-09-24
影响因子：
--
作者：
Xie L;Chao X;Teng T;Li Q;Xie J
通讯作者：
Xie J