Inter-observer variability of organ contouring for preclinical studies with cone beam Computed Tomography imaging.
Inter-observer variability of organ contouring for preclinical studies with cone beam Computed Tomography imaging.
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DOI：
10.1016/j.phro.2022.01.002
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发表时间：
2022-01
影响因子：
--
通讯作者：
Verhaegen F
中科院分区：
文献类型：
--
作者：
Lappas G;Staut N;Lieuwes NG;Biemans R;Wolfs CJA;van Hoof SJ;Dubois LJ;Verhaegen F
在临床前放射研究中，对健康组织的放射反应进行量化是一个很有兴趣的问题。人工轮廓对治疗计划有重大影响，因为人工解释引入了变化。这导致在评估正常组织体积时不一致。对这些差异的评估可以更好地了解当前临床前放射工作流程的局限性。在本工作中，评估了在锥形束计算机断层扫描上对头部和胸部区域的啮齿动物正常组织进行手动轮廓的观察者间变异性（IOV）。两名动物技术人员手动（辅助）绘制位于啮齿动物胸部和头部区域的正常组织轮廓，每个身体部位20例。计算两个观测者轮廓之间的平均表面距离（MSD）、质心位移（ΔCoM）、DICE相似系数（DSC）和第95百分位豪斯多夫距离（HD95）来评估IOV。胸腔器官,对肺IOV最低(ΔCoM: 0.08 ±0.04 mm, DSC: 0.96±0.01 ,MSD: 0.07±0.01 mm, HD95:0.20 ±0.03 毫米)脊髓,最高IOV(ΔCoM: 0.5 ±0.3 mm, DSC: 0.81±0.05 ,MSD: 0.14±0.03 mm, HD95:0.8 ±0.2 毫米)。有关主管机关,右眼IOV最低(ΔCoM: 0.12 ±0.08 mm, DSC: 0.93±0.02 ,MSD: 0.15±0.04 mm, HD95: 0.29±0.07 毫米)而完整的大脑,最高IOV(ΔCoM: 0.2 ±0.1 mm, DSC: 0.94±0.02 ,MSD: 0.3±0.1 mm, HD95: 0.5±0.1 毫米)。我们的发现揭示了啮齿动物胸部和头部正常组织的小IOV，在亚毫米范围内。所述轮廓集可作为开发用于例如治疗计划的自动描绘方法的基础。
In preclinical radiation studies, there is great interest in quantifying the radiation response of healthy tissues. Manual contouring has significant impact on the treatment-planning because of variation introduced by human interpretation. This results in inconsistencies when assessing normal tissue volumes. Evaluation of these discrepancies can provide a better understanding on the limitations of the current preclinical radiation workflow. In the present work, interobserver variability (IOV) in manual contouring of rodent normal tissues on cone-beam Computed Tomography, in head and thorax regions was evaluated. Two animal technicians performed manually (assisted) contouring of normal tissues located within the thorax and head regions of rodents, 20 cases per body site. Mean surface distance (MSD), displacement of center of mass (ΔCoM), DICE similarity coefficient (DSC) and the 95th percentile Hausdorff distance (HD95) were calculated between the contours of the two observers to evaluate the IOV. For the thorax organs, right lung had the lowest IOV (ΔCoM: 0.08 ± 0.04 mm, DSC: 0.96 ± 0.01, MSD:0.07 ± 0.01 mm, HD95:0.20 ± 0.03 mm) while spinal cord, the highest IOV (ΔCoM:0.5 ± 0.3 mm, DSC:0.81 ± 0.05, MSD:0.14 ± 0.03 mm, HD95:0.8 ± 0.2 mm). Regarding head organs, right eye demonstrated the lowest IOV (ΔCoM:0.12 ± 0.08 mm, DSC: 0.93 ± 0.02, MSD: 0.15 ± 0.04 mm, HD95: 0.29 ± 0.07 mm) while complete brain, the highest IOV (ΔCoM: 0.2 ± 0.1 mm, DSC: 0.94 ± 0.02, MSD: 0.3 ± 0.1 mm, HD95: 0.5 ± 0.1 mm). Our findings reveal small IOV, within the sub-mm range, for thorax and head normal tissues in rodents. The set of contours can serve as a basis for developing an automated delineation method for e.g., treatment planning.
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DOI：
10.1186/s13014-020-01677-2
发表时间：
2021-06-28
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
van der Veen J;Gulyban A;Willems S;Maes F;Nuyts S
通讯作者：
Nuyts S
影响因子：
--
作者：
Vaassen F;Hazelaar C;Vaniqui A;Gooding M;van der Heyden B;Canters R;van Elmpt W
通讯作者：
van Elmpt W
影响因子：
4.3
作者：
Vande Velde G;Poelmans J;De Langhe E;Hillen A;Vanoirbeek J;Himmelreich U;Lories RJ
通讯作者：
Lories RJ
影响因子：
16.6
作者：
Schoppe O;Pan C;Coronel J;Mai H;Rong Z;Todorov MI;Müskes A;Navarro F;Li H;Ertürk A;Menze BH
通讯作者：
Menze BH
影响因子：
2
作者：
Tillner, Falk;Thute, Prasad;Enghardt, Wolfgang
通讯作者：
Enghardt, Wolfgang