SCUD: Saccharomyces cerevisiae ubiquitination database.
SCUD: Saccharomyces cerevisiae ubiquitination database.
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DOI：
10.1186/1471-2164-9-440
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发表时间：
2008-09-24
期刊：
影响因子：
4.4
通讯作者：
Kim D
中科院分区：
文献类型：
--
作者：
Lee WC;Lee M;Jung JW;Kim KP;Kim D
泛素化是一种重要的翻译后修饰，参与多种生物学过程。因此，一个物种的泛素化系统的全基因组代表性是重要的。SCUD是一个基于Web的酿酒酵母（面包酵母）泛素化系统数据库。我们首先搜索了所有已知的参与酵母中泛素化过程的酶，包括E1，E2，E3和去泛素化酶。然后，通过文献检索收集泛素化底物。特别是E3和去泛素化酶，根据它们的共同结构域和独特功能分为类和亚类。结果，42种不同的E3酶被分为相应的类和亚类，并鉴定了940种泛素化底物，包括突变底物。所有酶和底物信息都通过超链接相互连接，这使得查看酶特异性遍在化信息变得容易。该数据库旨在代表一个全面的酵母泛素化系统，并易于扩展与进一步的实验数据。我们希望该数据库将有助于其他高等生物的泛素化系统的研究。飞毛腿可以在
Ubiquitination is an important post-translational modification involved in diverse biological processes. Therefore, genomewide representation of the ubiquitination system for a species is important. SCUD is a web-based database for the ubiquitination system in Saccharomyces cerevisiae (Baker's yeast). We first searched for all the known enzymes involved in the ubiquitination process in yeast, including E1, E2, E3, and deubiquitination enzymes. Then, ubiquitinated substrates were collected by literature search. Especially, E3 and deubiquitination enzymes are classified into classes and subclasses by their shared domains and unique functions. As a result, 42 different E3 enzymes were grouped into corresponding classes and subclasses, and 940 ubiquitinated substrates including mutant substrates were identified. All the enzyme and substrate information are interconnected by hyperlinks, which makes it easy to view the enzyme-specific ubiquitination information. This database aims to represent a comprehensive yeast ubiquitination system, and is easily expandable with the further experimental data. We expect that this database will be useful for the research on the ubiquitination systems of other higher organisms. SCUD is accessible at
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影响因子：
64.5
作者：
Koegl, M;Hoppe, T;Jentsch, S
通讯作者：
Jentsch, S
影响因子：
4.8
作者：
JOHNSON, ES;MA, PCM;VARSHAVSKY, A
通讯作者：
VARSHAVSKY, A
影响因子：
4.8
作者：
Kus, B;Gajadhar, A;Rotin, D
通讯作者：
Rotin, D
影响因子：
3
作者：
通讯作者：
--
影响因子：
7
作者：
Mayor, T;Lipford, JR;Deshaies, RJ
通讯作者：
Deshaies, RJ