The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews.
The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews.
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DOI：
10.1037/bul0000333
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发表时间：
2021-10
影响因子：
22.4
通讯作者：
Sher KJ
中科院分区：
文献类型：
--
作者：
Boness CL;Watts AL;Moeller KN;Sher KJ
现代疾病分类学（例如，ICD-11，DSM-5）对酒精使用障碍（AUD）和依赖的诊断优先考虑可靠性和临床表现，而不是病因，导致诊断并不总是基于基础理论和研究。在这些疾病分类中，DSM-5 AUD被视为一种离散的、主要分类的、但分级的现象，这导致了额外的挑战（例如，显著的表型异质性）。努力增加AUD诊断与酒精依赖的现代概念化之间的兼容性，将其描述为维度并与其他精神病理学部分重叠（例如，其他物质使用障碍）将激发更强大的科学框架，并加强AUD的有效性。我们对144篇综述进行了系统回顾，将成瘾结构和理论整合到一个全面的框架中，旨在确定与AUD有关的基本机制。这一努力的产物是AUD机制的病因学、基于理论的个体发生层次框架（ETOH框架），该框架概述了认知控制、奖励以及负效价和情绪性的超域，其中每个超域都是较窄的、层次组织的组成部分。我们还概述了对手的过程和自我意识的AUD机制的关键主持人。与其他框架相比，我们建议增加负效价和强迫在AUD中的概念作用。ETOH框架是将AUD概念化为多维和异质的关键一步。它有可能改善AUD评估，并有助于制定基于证据的诊断措施，重点关注AUD的关键机制，从而促进治疗匹配。
Modern nosologies (e.g., ICD-11, DSM-5) for alcohol use disorder (AUD) and dependence prioritize reliability and clinical presentation over etiology, resulting in a diagnosis that is not always strongly grounded in basic theory and research. Within these nosologies, DSM-5 AUD is treated as a discrete, largely categorical, but graded, phenomenon, which results in additional challenges (e.g., significant phenotypic heterogeneity). Efforts to increase the compatibility between AUD diagnosis and modern conceptualizations of alcohol dependence, which describe it as dimensional and partially overlapping with other psychopathology (e.g., other substance use disorders) will inspire a stronger scientific framework and strengthen AUD’s validity. We conducted a systematic review of 144 reviews to integrate addiction constructs and theories into a comprehensive framework with the aim of identifying fundamental mechanisms implicated in AUD. The product of this effort was the Etiologic, Theory-Based, Ontogenetic Hierarchical Framework (ETOH Framework) of AUD mechanisms, which outlines superdomains of cognitive control, reward, as well as negative valence and emotionality, each of which subsume narrower, hierarchically-organized components. We also outline opponent processes and self-awareness as key moderators of AUD mechanisms. In contrast with other frameworks, we recommend an increased conceptual role for negative valence and compulsion in AUD. The ETOH framework serves as a critical step towards conceptualizations of AUD as dimensional and heterogeneous. It has the potential to improve AUD assessment and aid in the development of evidence-based diagnostic measures that focus on key mechanisms in AUD, consequently facilitating treatment matching.
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DOI：
10.1111/add.13535
发表时间：
2017-01
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Amlung M;Vedelago L;Acker J;Balodis I;MacKillop J
通讯作者：
MacKillop J
DOI：
10.1037/adb0000341
发表时间：
2018-03
期刊：
Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
影响因子：
--
作者：
Bailey AJ;Gerst K;Finn PR
通讯作者：
Finn PR
影响因子：
25.8
作者：
Amlung, Michael;Marsden, Emma;McCabe, Randi E.
通讯作者：
McCabe, Randi E.
DOI：
10.3109/10826089009067006
发表时间：
1990-01-01
期刊：
INTERNATIONAL JOURNAL OF THE ADDICTIONS
影响因子：
--
作者：
ANTHENELLI, RM;SCHUCKIT, MA
通讯作者：
SCHUCKIT, MA
DOI：
10.1111/j.1521-0391.2014.12147.x
发表时间：
2014-11
期刊：
The American journal on addictions
影响因子：
--
作者：
Zuo L;Lu L;Tan Y;Pan X;Cai Y;Wang X;Hong J;Zhong C;Wang F;Zhang XY;Vanderlinden LA;Tabakoff B;Luo X
通讯作者：
Luo X