Comorbidity in elderly cancer patients in relation to overall and cancer-specific mortality.
Comorbidity in elderly cancer patients in relation to overall and cancer-specific mortality.
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DOI：
10.1038/bjc.2012.46
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发表时间：
2012-03-27
影响因子：
8.8
通讯作者：
Herrstedt, J.
中科院分区：
文献类型：
--
作者：
Jorgensen, T. L.;Hallas, J.;Friis, S.;Herrstedt, J.
本研究的目的是描述与背景人群相比，新诊断的老年癌症病例中合并症的患病率，并描述其对总体死亡率和癌症死亡率的影响。对丹麦某个省份 1996 年 1 月 1 日至 2006 年 12 月 31 日期间诊断患有乳腺癌、肺癌、结直肠癌、前列腺癌或卵巢癌的所有 70 岁以上老年人进行的基于人群的研究。合并症根据查尔森合并症指数 (CCI) 进行测量。采用条件logistic回归比较初诊癌症患者与对照组的合并症患病率，并采用Cox比例风险法分析合并症对死亡率的影响。总共发现了 6325 例癌症病例。老年肺癌和结直肠癌患者的合并症明显多于背景人群。严重合并症与肺癌、结直肠癌和前列腺癌患者较高的总体死亡率相关，风险比分别为 1.51 (95% CI 1.24–1.83)、1.41 (95% CI 1.14–1.73) 和 2.14 (95% CI 1.65–2.77)。一般来说，合并症并不影响癌症特异性死亡率。与背景人群相比，结直肠癌和肺癌与老年人合并症负担增加相关。合并症与老年癌症患者总体死亡率增加相关，但与癌症特异性死亡率不一致。
Aims of this study were to describe the prevalence of comorbidity in newly diagnosed elderly cancer cases compared with the background population and to describe its influence on overall and cancer mortality. Population-based study of all 70+ year-olds in a Danish province diagnosed with breast, lung, colorectal, prostate, or ovarian cancer from 1 January 1996 to 31 December 2006. Comorbidity was measured according to Charlson's comorbidity index (CCI). Prevalence of comorbidity in newly diagnosed cancer patients was compared with a control group by conditional logistic regression, and influence of comorbidity on mortality was analysed by Cox proportional hazards method. A total of 6325 incident cancer cases were identified. Elderly lung and colorectal cancer patients had significantly more comorbidity than the background population. Severe comorbidity was associated with higher overall mortality in the lung, colorectal, and prostate cancer patients, hazard ratios 1.51 (95% CI 1.24–1.83), 1.41 (95% CI 1.14–1.73), and 2.14 (95% CI 1.65–2.77), respectively. Comorbidity did not affect cancer-specific mortality in general. Colorectal and lung cancer was associated with increased comorbidity burden in the elderly compared with the background population. Comorbidity was associated with increased overall mortality in elderly cancer patients but not consistently with cancer-specific mortality.
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影响因子：
1.9
作者：
HALLAS, J;LAURITSEN, J;GRAM, LF
通讯作者：
GRAM, LF
影响因子：
3
作者：
Jorgensen, T. L.;Herrstedt, J.;Hallas, J.
通讯作者：
Hallas, J.
影响因子：
6.7
作者：
Gullon Blanco, Jose Antonio;Toste, Isabel Suarez;Gonzalez Martin, Isidro Jesus
通讯作者：
Gonzalez Martin, Isidro Jesus
影响因子：
45.3
作者：
Asmis, Timothy R.;Ding, Keyue;Goss, Glenwood D.
通讯作者：
Goss, Glenwood D.
影响因子：
4.7
作者：
Maas, HAAM;Kruitwagen, RFPM;Janssen-Heijnen, MLG
通讯作者：
Janssen-Heijnen, MLG