Nhatrangins A and B, aplysiatoxin-related metabolites from the marine cyanobacterium Lyngbya majuscula from Vietnam.
Nhatrangins A and B, aplysiatoxin-related metabolites from the marine cyanobacterium Lyngbya majuscula from Vietnam.
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DOI：
10.1021/np100002q
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发表时间：
2010-04-23
影响因子：
5.1
通讯作者：
Orjala J
中科院分区：
文献类型：
--
作者：
Chlipala GE;Pham HT;Nguyen VH;Krunic A;Shim SH;Soejarto DD;Orjala J
从越南一种野林草（lingbya majuscula）中分离到两种多酮代谢产物nhatrangins A(1)和B(2)。这些化合物与应用毒素系列的代谢物有关，这些代谢物也从这种海洋蓝藻中分离出来。使用900 MHz冷冻探针核磁共振可以从大约0.3 mg的化合物中解析出1的二维结构。LC-MS分析用于指导额外物质的分离以及2。采用J-based耦合常数分析和选择性NOE实验完成构象分析。
Two polyketide metabolites, nhatrangins A (1) and B (2), were isolated from a Vietnamese collection of Lyngbya majuscula. These compounds are related to the aplysiatoxin series of metabolites, which have also been isolated from this species of marine cyanobacterium. The use of 900 MHz cryoprobe NMR allowed the elucidation of the 2D structure of 1 from approximately 0.3 mg of compound. LC-MS analysis was utilized to direct the isolation of additional material as well as the isolation of 2. Conformational analysis was completed using J-based coupling constant analysis and selective NOE experiments.
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