Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch.
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch.
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DOI：
10.1186/1477-7525-8-52
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发表时间：
2010-05-21
影响因子：
3.6
通讯作者：
Natvig GK
中科院分区：
文献类型：
--
作者：
Andersen JR;Aasprang A;Bergsholm P;Sletteskog N;Våge V;Natvig GK
病态肥胖症患者患焦虑和抑郁的风险增加。“十二指肠转移术”可能是最有效的减肥手术。然而，据我们所知，关于十二指肠切换术后焦虑和抑郁症状的数据缺乏。此外，有人假设，自我报告的身体健康状况是病态肥胖患者抑郁症状的主要预测因素。因此，我们调查了十二指肠代偿手术前后焦虑和抑郁的症状，以及术后自我报告的身体健康状况的变化是否预示着这些症状的变化。分别于术前(n=50)、术后一年(n=47)和二年(n=44)进行数据评估。焦虑、抑郁症状采用《医院焦虑抑郁量表》进行评定，自报身体健康状况采用《简明36》问卷进行评定。采用线性混合效应模型研究焦虑和抑郁症状的变化。使用相关和线性多元回归分析来研究自我报告的身体健康的变化是否可以预测术后焦虑和抑郁症状的变化。焦虑、抑郁症状负担在术前较高，术后一、两年恢复正常(P<；0.001)。自我报告的身体健康的改善程度与焦虑(P=0.003)和抑郁(P=0.004)症状的显著减少有关。这项研究的新颖性在于十二指肠转移术后焦虑和抑郁症状的大幅和持续减少，并且这些变化与自我报告的身体健康的改善密切相关。
Patients with morbid obesity have an increased risk for anxiety and depression. The "duodenal switch" is perhaps the most effective obesity surgery procedure for inducing weight loss. However, to our knowledge, data on symptoms of anxiety and depression after the duodenal switch are lacking. Furthermore, it has been hypothesized that self-reported physical health is the major predictor of symptoms of depression in patients with morbid obesity. We therefore investigated the symptoms of anxiety and depression before and after the duodenal switch procedure and whether post-operative changes in self-reported physical health were predictive of changes in these symptoms. Data were assessed before surgery (n = 50), and one (n = 47) and two (n = 44) years afterwards. Symptoms of anxiety and depression were assessed by the "Hospital Anxiety and Depression Scale", and self-reported physical health was assessed by the "Short-Form 36" questionnaire. Linear mixed effect models were used to investigate changes in the symptoms of anxiety and depression. Correlation and linear multiple regression analyses were used to study whether changes in self-reported physical health were predictive of post-operative changes in the symptoms of anxiety and depression. The symptom burden of anxiety and depression were high before surgery but were normalized one and two years afterwards (P < 0.001). The degree of improvement in self-reported physical health was associated with statistically significant reductions in the symptoms of anxiety (P = 0.003) and depression (P = 0.004). The novelty of this study is the large and sustained reductions in the symptoms of anxiety and depression after the duodenal switch procedure, and that these changes were closely associated with improvements in self-reported physical health.
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影响因子：
2.9
作者：
Carmichael, AR;Sue-Ling, HM;Johnston, D
通讯作者：
Johnston, D
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3
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2.9
作者：
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通讯作者：
Faith, MS
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2.9
作者：
Potoczna, Natascha;Harfmann, Susanne;Horber, Fritz F.
通讯作者：
Horber, Fritz F.