Circulating levels of cytokines, chemokines and growth factors in patients with achalasia.
Circulating levels of cytokines, chemokines and growth factors in patients with achalasia.
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DOI：
10.3892/br.2021.1468
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发表时间：
2021-11
影响因子：
2.3
通讯作者：
Latiano A
中科院分区：
文献类型：
--
作者：
Panza A;Fontana A;Palmieri O;Merla A;Copetti M;Cuttitta A;Biscaglia G;Gentile A;Andriulli A;Latiano A
特发性贲门失弛缓症是一种以食管下括约肌无松弛和不完全松弛为特征的疾病，伴有吞咽困难、反流、胸痛和体重减轻。尽管先前已经在组织学和组织化学上表征了组织中的浸润细胞概况，但是炎性浸润在贲门失弛缓症发病机制中的作用仍然存在争议。本研究旨在评估27种蛋白质生物标志物的血清水平，以确定其与贲门失弛缓症和临床疾病特征的相关性。使用27-Bio-Pro人细胞因子测定法对68例贲门失弛缓症患者和39例健康个体的细胞因子、趋化因子和生长因子血清谱进行了探索。炎症介质IL-1 β、IL-2、IL-5、IL-6、IL-8、IL-10、IL-12 p70、IL-13、IL-15、IL-17、成纤维细胞生长因子、粒细胞集落刺激因子、粒细胞-巨噬细胞集落刺激因子、干扰素-γ、单核细胞趋化蛋白-1、巨噬细胞炎症蛋白-1（MIP-1）α和MIP-1 β水平降低，贲门失弛缓症患者血清中TNF-α和VEGF的表达水平与正常对照组比较有显著性差异（P <0.05）。而炎症因子的表达水平与患者的临床特征无明显相关性（P> 0.05）。这些结果表明，贲门失弛缓症是一种疾病，有一个局部，但不是全身炎症模式。需要进一步的研究来提高目前对这种疾病的机制的理解。
Idiopathic achalasia is a disease that is characterized by the absence of peristalsis and incomplete relaxation of the lower esophageal sphincter, which is accompanied by dysphagia, regurgitation, chest pain and weight loss. The role of inflammatory infiltrates in the pathogenesis of achalasia remains controversial, although the infiltrating cell profile in the tissue has been previously characterized histologically and immunohistochemically. The present study aimed to evaluate the serum levels of 27 protein biomarkers to determine their association with achalasia and the clinical disease characteristics. The cytokine, chemokine and growth factor serum profiles of 68 patients with achalasia and 39 healthy individuals were explored using the 27-Bio-Plex Pro Human Cytokine assay. Reductions in the levels of inflammatory mediators IL-1β, IL-2, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-15, IL-17, fibroblast growth factor, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, interferon-γ, monocyte chemoattractant protein-1, macrophage inflammatory protein-1 (MIP-1)α and MIP-1β, regulated upon activation normal T cell expressed and presumably secreted, TNF-α and VEGF were detected in the serum samples of patients with achalasia compared with those in the control group (P<0.05). However, significant associations between the expression in the levels of inflammatory factors and clinical characteristics of the patients were not found (P>0.05). These results suggest that achalasia is a disease that has a local but not a systemic inflammatory pattern. Further studies are required to improve the current understanding of the mechanism underlying this disease.
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影响因子：
15.3
作者：
Hirota, H;Kiyama, H;Kishimoto, T;Taga, T
通讯作者：
Taga, T
影响因子：
4.6
作者：
Kleiner G;Marcuzzi A;Zanin V;Monasta L;Zauli G
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Zauli G
影响因子：
4.3
作者：
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通讯作者：
Torres-Villalobos G
DOI：
10.1007/s11938-005-0020-1
发表时间：
2005-08-01
期刊：
Current treatment options in gastroenterology
影响因子：
--
作者：
Richter, Joel E
通讯作者：
Richter, Joel E
影响因子：
2.7
作者：
Wang, Zeyu;Zhang, Jun;Zhao, Dongqiang
通讯作者：
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