Cytokine levels in the serum of healthy subjects.
Cytokine levels in the serum of healthy subjects.
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DOI：
10.1155/2013/434010
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发表时间：
2013
影响因子：
4.6
通讯作者：
Zauli G
中科院分区：
文献类型：
--
作者：
Kleiner G;Marcuzzi A;Zanin V;Monasta L;Zauli G
关于细胞因子网络反应的知识不断增长，导致了对病理机制的更好理解，并开发了能够阻断免疫反应的特定分子的生物药物的新治疗方法。事实上，当细胞因子的产生失调时，疾病经常发生。了解细胞因子网络的生理机制将有助于更好地理解病理条件。此外，由于免疫系统和免疫反应会随着发育而改变其特性，因此应考虑患者在生理和病理条件下的年龄差异。在这项研究中，我们分析了健康受试者血清中48种细胞因子和趋化因子的谱，比较了成人（≥18岁）与幼儿和儿童（1-6岁和7-17岁）。我们发现，健康受试者中不产生一定数量的细胞因子;其他人显示出恒定的血清水平。某些细胞因子随着年龄的增加而呈现下降或上升的趋势。其余的细胞因子在儿童组中相对于其他组上调或下调。总之，我们得出了一些关于细胞因子和趋化因子的生理产生的指南，这些指南是基于衰老引起的差异。
Growing knowledge about the cytokine network response has led to a better comprehension of mechanisms of pathologies and to the development of new treatments with biological drugs, able to block specific molecules of the immune response. Indeed, when the cytokine production is deregulated, diseases often occur. The understanding of the physiological mechanism of the cytokine network would be useful to better comprehend pathological conditions. Moreover, since the immune system and response change their properties with development, differences in patients' age should be taken into account, both in physiological and in pathological conditions. In this study, we analyzed the profile of 48 cytokines and chemokines in the serum of healthy subjects, comparing adults (≥18 years) with young children and children (1–6 and 7–17 years). We found that a certain number of cytokines were not being produced in healthy subjects; others showed a constant serum level amongst the groups. Certain cytokines exhibited a downward or an upward trend with increasing age. The remaining cytokines were up- or downregulated in the group of the children with respect to the other groups. In conclusion, we drew some kinds of guidelines about the physiological production of cytokines and chemokines, underling the difference caused by aging.
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影响因子：
3.5
作者：
Alam, Athar;Pal, Chinmay;Bandyopadhyay, Uday
通讯作者：
Bandyopadhyay, Uday
影响因子：
5.5
作者：
Braun, J;Baraliakos, X;Sieper, J
通讯作者：
Sieper, J
影响因子：
3.7
作者：
Raman D;Sobolik-Delmaire T;Richmond A
通讯作者：
Richmond A
影响因子：
56.9
作者：
Dostert, Catherine;Petrilli, Virginie;Tschopp, Jurg
通讯作者：
Tschopp, Jurg
健康与疾病中的白介素5和IL-5受体。
DOI：
10.2183/pjab.87.463
发表时间：
2011
期刊：
Proceedings of the Japan Academy. Series B, Physical and biological sciences
影响因子：
--
作者：
Takatsu K
通讯作者：
Takatsu K