Gene regulation by RNA binding proteins and microRNAs in angiogenesis.
Gene regulation by RNA binding proteins and microRNAs in angiogenesis.
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DOI：
10.1016/j.molmed.2011.06.008
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发表时间：
2011-11
影响因子：
13.6
通讯作者：
Hla T
中科院分区：
文献类型：
--
作者：
Chang SH;Hla T
一旦mRNA被转录、剪接并转运到细胞质，它们的命运就由RNA结合蛋白（RBP）和作用于转录物内的调控元件的微小RNA（miRNA）的复杂相互作用决定。转录后调节机制在血管生成中的重要性通过以下观察而得到强调：miRNA和/或RBP中的扰动导致血管发育、稳态和疾病中的深刻表型改变，目前的数据表明关键血管生成调节因子（分泌因子和细胞内信号传导中间体）的mRNA受到RBP和miRNA的严格转录后调节。此外，miRNA和RBP的复杂网络允许在血管细胞中进行稳健的基因调控。本文就miRNAs和RBPs在血管生成调控基因时空调控中的作用进行综述。
Once mRNAs are transcribed, spliced and transported to the cytoplasm, their fate is determined by the complex interplay of RNA binding proteins (RBPs) and microRNAs (miRNAs) that act on regulatory elements within the transcripts. The importance of post-transcriptional regulatory mechanisms in angiogenesis is underscored by the observation that perturbations in miRNAs and/or RBPs lead to profound phenotypic alterations in vascular development, homeostasis and disease, with current data suggesting that mRNAs for key angiogenic regulators (secreted factors and intracellular signaling intermediates) are subject to stringent post-transcriptional regulation by both RBPs and miRNAs. In addition, an intricate network of miRNAs and RBPs allow robust gene regulation in vascular cells. This review focuses on the miRNAs and RBPs which often cooperate to achieve precise spatial and temporal control of angiogenic regulatory genes.
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