Single-Membrane-Bound Organelles: Division and Inheritance
Single-Membrane-Bound Organelles: Division and Inheritance
复制标题
单膜结合细胞器：分裂和继承
DOI：
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
S. Miyagishima
中科院分区：
文献类型：
--
作者：
F. Yagisawa;Yuuta Imoto;T. Fujiwara;S. Miyagishima
C. merolae细胞含有四种类型的单膜结合细胞器-ER、高尔基体、空泡/溶酶体和过氧化物酶体-其动力学已通过荧光显微镜和电子显微镜在细胞周期期间进行了研究。ER在整个细胞周期中保持一定的完整性，并通过纺锤体延伸分配给子细胞。高尔基体在M期之前增殖，并且靠近纺锤体极，它们与纺锤体极一起遗传。在M期之前，胞浆素增殖并向线粒体迁移，并且通过与线粒体结合，它们被子细胞遗传。这种结合需要卷曲螺旋蛋白，液泡遗传基因1（VIG 1）。过氧化物酶体在线粒体分裂前与线粒体的分裂平面相关联，之后它们分裂-依赖于发动蛋白和过氧化物酶体分裂（POD）机制的过程-并且与分裂的线粒体一起遗传。液泡和过氧化物酶体的遗传依赖于纺锤体，因为它是线粒体遗传所必需的。由于纺锤体分离染色体，所有单膜结合细胞器的遗传通过纺锤体与染色体遗传耦合。这种耦合允许细胞保留细胞器并在细胞分裂后保持功能。
C. merolae cells contain four types of single-membrane-bound organelles—the ER, Golgi bodies, vacuoles/lysosomes, and peroxisomes—the dynamics of which have been studied during the cell cycle by fluorescence microscopy and electron microscopy. The ER retains some integrity throughout the cell cycle and is apportioned to daughter cells by spindle elongation. Golgi bodies proliferate prior to M phase and lie close to the spindle poles, with which they are inherited. Vacuoles proliferate and migrate toward mitochondria before M phase, and by binding to the mitochondria, they become inherited by daughter cells. This binding requires a coiled-coil protein, vacuole inheritance gene 1 (VIG1). Peroxisomes associate with the division planes of mitochondria before mitochondrial division, after which they divide—a process that is dependent on dynamin and peroxisome-dividing (POD) machinery—and are inherited with the divided mitochondria. The inheritance of vacuoles and peroxisomes relies on the spindle, because it is required for mitochondrial inheritance. Because the spindle segregates chromosomes, the inheritance of all single-membrane-bound organelles is coupled to chromosomal inheritance via the spindle. This coupling allows cells to retain organelles and remain functional after cell division.
影响因子：
11.8
作者：
Hoenscher, Canna;Mari, Muriel;Ungermann, Christian
通讯作者：
Ungermann, Christian
影响因子：
3.3
作者：
Gandre-Babbe, Shilpa;van der Bliek, Alexander M.
通讯作者：
van der Bliek, Alexander M.
影响因子：
8.8
作者：
Sundborger AC;Fang S;Heymann JA;Ray P;Chappie JS;Hinshaw JE
通讯作者：
Hinshaw JE